Sortilin/neurotensin receptor-3: a new tool to investigate neurotensin signaling and cellular trafficking?
| Autor: | Jean Mazella |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Neurotensin receptor 3
Cloning Organism Neuropeptide Nerve Tissue Proteins Biology chemistry.chemical_compound Animals Humans Receptors Neurotensin Scavenger receptor Receptors Immunologic Receptor Neurotensin Receptors Lipoprotein Receptors Scavenger Membrane Glycoproteins Signal transducing adaptor protein Brain Membrane Proteins Cell Biology Scavenger Receptors Class B Cell biology Vesicular transport protein Adaptor Proteins Vesicular Transport Protein Transport chemistry Membrane protein Biochemistry Protein Processing Post-Translational Signal Transduction |
| Zdroj: | Cellular signalling. 13(1) |
| ISSN: | 0898-6568 |
| Popis: | The identification of gp95sortilin, a sorting protein, as being the 100 kDa neurotensin (NT) receptor, a non-G-protein coupled receptor, constitutes a new and interesting but intriguing step in the neuropeptide signaling as well as in cellular trafficking. The isolation of the same protein by three different experimental approaches sum up the complexity for researchers involved in the functional significance of the so-called sortilin/neurotensin receptor 3 (NTR3). This review will concentrate on the putative physiological and cellular roles of sortilin/NTR3 as most results so far have proposed hypothetical conclusions rather than concrete evidence. |
| Databáze: | OpenAIRE |
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