A failure of suppression within the default mode network in depressed adolescents with compulsive internet game play
Autor: | Sun Mi Kim, Doug Hyun Han, Perry F. Renshaw, Sujin Bae, Jeffrey S. Anderson |
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Rok vydání: | 2015 |
Předmět: |
Male
medicine.medical_specialty Adolescent Intraparietal sulcus Comorbidity Audiology behavioral disciplines and activities 03 medical and health sciences Young Adult 0302 clinical medicine Wisconsin Card Sorting Test medicine Humans Psychiatry Video game Anterior cingulate cortex Default mode network Depression (differential diagnoses) Depressive Disorder Major Internet medicine.disease 030227 psychiatry Psychiatry and Mental health Clinical Psychology medicine.anatomical_structure Video Games Compulsive behavior Case-Control Studies Compulsive Behavior Major depressive disorder medicine.symptom Psychology 030217 neurology & neurosurgery |
Zdroj: | Journal of affective disorders. 194 |
ISSN: | 1573-2517 |
Popis: | Background Individuals who are chronic, compulsive video game players experience an elevated incidence of major depression. Excessive or problematic game play can interact with depression clinically, and may magnify impulsive behavior associated with video gaming. Methods Functional brain imaging was performed during a Wisconsin Card Sorting Test (WCST) task in 42 healthy control and 95 volunteers seeking treatment for compulsive video game playing, including 60 participants without major depression (pure internet gaming disorder, pure IGD) and 35 participants comorbid with major depression (IGD+MDD). Results In response to the WCST in contrast to fixation, activation was observed in canonical brain attentional networks including bilateral intraparietal sulcus, frontal eye fields, and middle temporal cortical regions as well as dorsolateral prefrontal, inferior parietal and anterior insula, anterior cingulate cortex in all participants. For WCST>Fixation contrasts, the IGD+MDD group exhibited greater relative activation within the left hippocampus, compared to healthy control participants. For WCST>Fixation contrasts, the IGD+MDD group exhibited greater relative activation within the left hippocampus and the right parahippocampal gyrus immediately posterior to the hippocampus, compared to the pure IGD group. Conclusions In cohorts of individuals with a history of compulsive internet game play, individuals with depression showed failure to suppress default mode network activity during an attentionally demanding task, compared to individuals without depression, including comparison groups with and without a history of compulsive video gaming. This reduced suppression of the brain regions within the default mode network may be a consequence of depressive neurophysiology or represent a predisposition for depression within compulsive game players. |
Databáze: | OpenAIRE |
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