Injury-induced activation of ERK 1/2 in the sciatic nerve of healthy and diabetic rats
| Autor: | Martin Kanje, Lena Stenberg, Lars B. Dahlin, Lisa Mårtensson |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
MAPK/ERK pathway
medicine.medical_specialty Time Factors Diabetes Mellitus Experimental Lesion Diabetes mellitus Internal medicine medicine Animals Phosphorylation Rats Wistar Mitogen-Activated Protein Kinase 1 Mitogen-Activated Protein Kinase 3 Kinase business.industry General Neuroscience Nerve injury Streptozotocin medicine.disease Sciatic Nerve Axons Rats Endocrinology Immunohistochemistry Female Sciatic nerve Schwann Cells medicine.symptom business medicine.drug |
| Zdroj: | Neuroreport. 22(2) |
| ISSN: | 1473-558X |
| Popis: | Phosphorylation of extracellular-signal-regulated kinase 1/2 (p-ERK 1/2) was investigated by immunohistochemistry at 30 min, 1 h, and 48 h after nerve transection in the sciatic nerve of healthy and diabetic [streptozotocin (STZ)-induced diabetes mellitus and BioBreeding (BB; i.e. DR.lyp/lyp or BBDP)] rats. Transection injury increased the intensity of p-ERK 1/2 in nerve stumps at all time points. Staining was confined to Schwann cells with occasional faint staining in single axons. In diabetic rats, a lower intensity of p-ERK 1/2 was found at 1 and 48 h in the distal and proximal nerve stumps compared with healthy rats. STZ-induced diabetic rats were not different from BB rats. p-ERK 1/2 is activated differentially in Schwann cells after nerve injury in diabetic rats, whereas activation in STZ-induced diabetic rats did not differ from BB rats. |
| Databáze: | OpenAIRE |
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