Long-term neuropsychological safety of subgenual cingulate gyrus deep brain stimulation for treatment-resistant depression
| Autor: | Marci Sinden, Nicholas M. Bogod, Vanessa G. DeFreitas, Christopher R. Honey, Ivan J. Torres, Andrew K. Howard, Magdalena Ilcewicz-Klimek, Cindy Woo, Raymond W. Lam, Lakshmi N. Yatham |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty Deep brain stimulation medicine.medical_treatment Deep Brain Stimulation Neuropsychological Tests Gyrus Cinguli Depressive Disorder Treatment-Resistant Physical medicine and rehabilitation Cognition Gyrus medicine Humans Psychiatry Depression (differential diagnoses) Psychiatric Status Rating Scales Neuropsychology Middle Aged medicine.disease Psychiatry and Mental health medicine.anatomical_structure Treatment Outcome Female Neurology (clinical) Outcome data Psychology Treatment-resistant depression Follow-Up Studies |
| Zdroj: | The Journal of neuropsychiatry and clinical neurosciences. 26(2) |
| ISSN: | 1545-7222 |
| Popis: | Deep brain stimulation (DBS) of the subgenual cingulate gyrus (SCG) is a promising investigational intervention for treatment-resistant depression (TRD), but long-term outcome data are limited. Serial neuropsychological evaluations, using a comprehensive battery, were conducted on four subjects with TRD prior to surgery, and up to 42 months post-operatively. Reliable change methodology suggested general stability and/or select statistically reliable improvement in cognitive abilities over time. This is the first known set of multi-year neuropsychological follow-up data for SCG DBS for TRD. Observed improvements are likely attributable to reduced depressive symptomatology, recovery of functional capacities, and/or specific practice effects of repeated assessment. |
| Databáze: | OpenAIRE |
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