Preventive skin analgesia with lidocaine patch for management of post‐thoracotomy pain: Results of a randomized, double blind, placebo controlled study

Autor: Caterina Pace, Roberto Cascone, Annalisa Carlucci, Beatrice Passavanti, Vincenzo Pota, Pasquale Sansone, Emanuele De Ruberto, Anna Cecilia Izzo, Caterina Aurilio, Alfonso Fiorelli, Paolo Chiodini, Mario Santini
Přispěvatelé: Fiorelli, Alfonso, Pace, Caterina, Cascone, Roberto, Carlucci, Annalisa, De Ruberto, Emanuele, Izzo, Anna Cecilia, Passavanti, Beatrice, Chiodini, Paolo, Pota, Vincenzo, Aurilio, Caterina, Santini, Mario, Sansone, Pasquale
Jazyk: angličtina
Rok vydání: 2019
Předmět:
0301 basic medicine
Pulmonary and Respiratory Medicine
Male
Vital capacity
Lidocaine
Placebo-controlled study
Transdermal Patch
Placebo
lcsh:RC254-282
post-thoracotomy pain
03 medical and health sciences
0302 clinical medicine
Double-Blind Method
post‐thoracotomy pain
Medicine
Humans
Respiratory function
Prospective Studies
Anesthetics
Local
Prospective cohort study
Pain Measurement
Pain
Postoperative
Morphine
business.industry
General Medicine
Original Articles
Lidocaine Patch
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
thoracic surgery
030104 developmental biology
Treatment Outcome
Oncology
Thoracotomy
030220 oncology & carcinogenesis
Anesthesia
pre-emptive analgesia
Lidocaine patch
Original Article
Administration
Intravenous
Female
Preventive Medicine
Analgesia
business
pre‐emptive analgesia
medicine.drug
Zdroj: Thoracic Cancer
Thoracic Cancer, Vol 10, Iss 4, Pp 631-641 (2019)
ISSN: 1759-7714
1759-7706
Popis: To evaluate whether pre-emptive skin analgesia using a lidocaine patch 5% would improve the effects of systemic morphine analgesia for controlling acute post-thoracotomy pain. Background: To evaluate whether pre-emptive skin analgesia using a lidocaine patch 5% would improve the effects of systemic morphine analgesia for controlling acute post-thoracotomy pain. Methods: This was a double-blind, placebo controlled, prospective study. Patients were randomly assigned to receive lidocaine 5% patch (lidocaine group) or a placebo (placebo group) three days before thoracotomy. Postoperative analgesia was induced in all cases with intravenous morphine analgesia. The intergroup differences were assessed in order to evaluate whether the lidocaine patch 5% would have effects on pain intensity when at rest and after coughing (primary end-point) on morphine consumption, on the recovery of respiratory function, and on peripheral painful pathways measured with N2 and P2 laser-evoked potential (secondary end-points). Results: A total of 90 patients were randomized, of whom 45 were allocated to the lidocaine group and 45 to the placebo group. Lidocaine compared with the placebo group showed a significant reduction in pain intensity both at rest (P = 0.013) and after coughing (P = 0.015), and in total morphine consumption (P = 0.001); and also showed a better recovery of flow expiratory volume in one second (P = 0.025) and of forced vital capacity (P = 0.037). The placebo group compared with the lidocaine group presented a reduction in amplitude of N2 (P = 0.001) and P2 (P = 0.03), and an increase in the latency of N2 (P = 0.023) and P2 (P = 0.025) laser-evoked potential. Conclusions: The preventive skin analgesia with lidocaine patch 5% seems to be a valid adjunct to intravenous morphine analgesia for controlling post-thoracotomy pain. However, our initial results should be corroborated/confirmed by larger studies.
Databáze: OpenAIRE
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