Dietary polyunsaturated fatty acids and non-digestible oligosaccharides reduce dermatitis in mice
Autor: | Christin Weise, Eric A F Van Tol, Dennis Ernst, Margitta Worm |
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Rok vydání: | 2013 |
Předmět: |
medicine.medical_specialty
Docosahexaenoic Acids Ovalbumin Immunology Dermatitis Pilot Projects Ascorbic Acid CD8-Positive T-Lymphocytes Mice chemistry.chemical_compound Oral administration Internal medicine Animals Humans Immunology and Allergy Medicine Mast Cells Glucans Skin chemistry.chemical_classification Mice Inbred BALB C Transepidermal water loss business.industry Polydextrose Galactooligosaccharide Dietary management Feeding Behavior Allergens Diet Endocrinology chemistry Docosahexaenoic acid Pediatrics Perinatology and Child Health Disease Progression Fatty Acids Unsaturated Cytokines Female Arachidonic acid business Polyunsaturated fatty acid |
Zdroj: | Pediatric Allergy and Immunology. 24:361-367 |
ISSN: | 0905-6157 |
Popis: | Background Oral administration of specific food ingredients can modify mucosal and systemic inflammatory processes. Such food components are fatty acids or carbohydrates. Nevertheless, little is known about the impact of oral administration of polyunsaturated fatty acids (PUFA) and non-digestible oligosaccharides on allergen-induced dermatitis. Method In this pilot study, skin inflammation was induced by serial epicutaneous OVA applications in OVA-sensitized mice. In parallel, mice were fed with solid food containing arachidonic acid/docosahexaenoic acid (AA/DHA), galactooligosaccharide/polydextrose (GOS/PDX) or their combination. Skin lesions were assessed by clinical skin score, but also skin barrier parameters, immunohistochemical analyses, and local cytokine expression profile. Results Both dietary AA/DHA and GOS/PDX significantly ameliorated the severity of allergen-induced dermatitis. The clinical improvement upon oral AA/DHA and GOS/PDX supplementation was associated with a reduction in transepidermal water loss and reduced KI-67 expression in the skin. Lesional CD8+ and mast cells were reduced in all treatment groups, but appeared to be most pronounced in combined AA/DHA/GOS/PDX-treated mice. Moreover, in GOS/PDX-treated mice, IFNγ and TGFβ expression was increased in skin lesions. Conclusion Dietary supplementation with DHA/AA and GOS/PDX ameliorates symptoms of allergen-induced dermatitis and may thus be beneficial in the dietary management of human atopic eczema. |
Databáze: | OpenAIRE |
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