Cohort profile: the ECHO prenatal and early childhood pathways to health consortium (ECHO-PATHWAYS)
| Autor: | Kaja Z LeWinn, Catherine J Karr, Marnie Hazlehurst, Kecia Carroll, Christine Loftus, Ruby Nguyen, Emily Barrett, Shanna H Swan, Adam A Szpiro, Alison Paquette, Paul Moore, Elizabeth Spalt, Lisa Younglove, Alexis Sullivan, Trina Colburn, Nora Byington, Lauren Sims Taylor, Stacey Moe, Sarah Wang, Alana Cordeiro, Aria Mattias, Jennifer Powell, Tye Johnson, Amanda Norona-Zhou, Alex Mason, Nicole R Bush, Sheela Sathyanarayana |
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| Rok vydání: | 2022 |
| Předmět: |
fetal medicine
Pediatric Research Initiative Adolescent Corticotropin-Releasing Hormone Placenta Clinical Sciences Reproductive health and childbirth Basic Behavioral and Social Science Cohort Studies Pregnancy Clinical Research 2.3 Psychological Behavioral and Social Science Humans 2.2 Factors relating to the physical environment 2.1 Biological and endogenous factors Climate-Related Exposures and Conditions Prospective Studies Conditions Affecting the Embryonic and Fetal Periods Aetiology Child Preschool Pediatric Other Medical and Health Sciences Prevention public health Neurosciences General Medicine Environmental Exposure Perinatal Period - Conditions Originating in Perinatal Period Mental Health Good Health and Well Being Child Preschool Prenatal Exposure Delayed Effects paediatric thoracic medicine Public Health and Health Services developmental neurology & neurodisability Female social and economic factors |
| Zdroj: | BMJ open, vol 12, iss 10 |
| Popis: | PurposeExposures early in life, beginning in utero, have long-term impacts on mental and physical health. The ECHO prenatal and early childhood pathways to health consortium (ECHO-PATHWAYS) was established to examine the independent and combined impact of pregnancy and childhood chemical exposures and psychosocial stressors on child neurodevelopment and airway health, as well as the placental mechanisms underlying these associations.ParticipantsThe ECHO-PATHWAYS consortium harmonises extant data from 2684 mother–child dyads in three pregnancy cohort studies (CANDLE [Conditions Affecting Neurocognitive Development and Learning in Early Childhood], TIDES [The Infant Development and Environment Study] and GAPPS [Global Alliance to Prevent Prematurity and Stillbirth]) and collects prospective data under a unified protocol. Study participants are socioeconomically diverse and include a large proportion of Black families (38% Black and 51% White), often under-represented in research. Children are currently 5–15 years old. New data collection includes multimodal assessments of primary outcomes (airway health and neurodevelopment) and exposures (air pollution, phthalates and psychosocial stress) as well as rich covariate characterisation. ECHO-PATHWAYS is compiling extant and new biospecimens in a central biorepository and generating the largest placental transcriptomics data set to date (N=1083).Findings to dateEarly analyses demonstrate adverse associations of prenatal exposure to air pollution, phthalates and maternal stress with early childhood airway outcomes and neurodevelopment. Placental transcriptomics work suggests that phthalate exposure alters placental gene expression, pointing to mechanistic pathways for the developmental toxicity of phthalates. We also observe associations between prenatal maternal stress and placental corticotropin releasing hormone, a marker of hormonal activation during pregnancy relevant for child health. Other publications describe novel methods for examining exposure mixtures and the development of a national spatiotemporal model of ambient outdoor air pollution.Future plansThe first wave of data from the unified protocol (child age 8–9) is nearly complete. Future work will leverage these data to examine the combined impact of early life social and chemical exposures on middle childhood health outcomes and underlying placental mechanisms. |
| Databáze: | OpenAIRE |
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