Version 3 of the National Alzheimer's Coordinating Center's Uniform Data Set
| Autor: | Helena C. Chui, Merilee Teylan, Nicole K. Thomas, John C. Morris, Margaret Dean, Lilah M. Besser, George Thomas, Duane Beekly, Joseph F. Quinn, Katya Rascovsky, Mark Bollenbeck, Walter A. Kukull, Jeffrey M. Burns, Creighton H. Phelps, Kristen Schwabe-Fry, Douglas Galasko, Mary Jacka, Elizabeth Robichaud, Sandra Weintraub, Xiao Hua Zhou, Gregory A. Jicha, Charles Mock, Janene L. Hubbard, Robert A. Sweet, Cynthia M. Carlsson, Joylee Wu, Sarah E. Monsell, David S. Knopman |
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| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty Consensus Databases Factual Computer science MEDLINE Review Article Neuropsychological Tests Information Centers Lewy body disease 03 medical and health sciences 0302 clinical medicine Alzheimer Disease medicine Humans Center (algebra and category theory) Medical physics Alzheimer disease center frontotemporal degeneration Aged Data collection 030214 geriatrics Task force Neuropsychological battery Middle Aged United States MCI 3. Good health Data set Psychiatry and Mental health Clinical Psychology Clinical diagnosis National Alzheimer’s Coordinating Center ComputingMethodologies_DOCUMENTANDTEXTPROCESSING Female Geriatrics and Gerontology Gerontology 030217 neurology & neurosurgery Dementia research |
| Zdroj: | Alzheimer Disease and Associated Disorders |
| ISSN: | 1546-4156 |
| Popis: | Supplemental Digital Content is available in the text. Introduction: In 2015, the US Alzheimer’s Disease Centers (ADC) implemented Version 3 of the Uniform Data Set (UDS). This paper describes the history of Version 3 development and the UDS data that are freely available to researchers. Methods: UDS Version 3 was developed after years of coordination between the National Institute on Aging-appointed Clinical Task Force (CTF), clinicians from ∼30 ADCs, and the National Alzheimer’s Coordinating Center (NACC). The CTF recognized the need for updates to align with the state of the science in dementia research, while being flexible to the diverse needs and diseases studied at the ADCs. Version 3 also developed a nonproprietary neuropsychological battery. Results: This paper focuses on the substantial Version 3 changes to the UDS forms related to clinical diagnosis and characterization of clinical symptoms to match updated consensus-based diagnostic criteria. Between March 2015 and March 2018, 4820 participants were enrolled using UDS Version 3. Longitudinal data were available for 25,337 of the 37,568 total participants using all UDS versions. Discussion: The results from utilization of the UDS highlight the possibility for numerous research institutions to successfully collaborate, produce, and use standardized data collection instruments for over a decade. |
| Databáze: | OpenAIRE |
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