Haemodynamic effects of heparin during coronary bypass surgery
| Autor: | E. Seem, Hysing E, Ulf E Kongsgaard, L. Bjørnskau, O Geiran, S. Tølløfsrud, N Smith-Erichsen |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Extracorporeal Circulation
Mean arterial pressure Cardiac output Kallikrein-Kinin System Bradykinin Blood Pressure chemistry.chemical_compound Double-Blind Method Humans Medicine cardiovascular diseases Cardiac Output Coronary Artery Bypass Heparin urogenital system business.industry Extracorporeal circulation Hemodynamics Prekallikrein General Medicine biological factors Anesthesiology and Pain Medicine Blood pressure medicine.anatomical_structure chemistry Bypass surgery Anesthesia Vascular resistance Kallikreins Vascular Resistance business circulatory and respiratory physiology medicine.drug |
| Zdroj: | Acta Anaesthesiologica Scandinavica. 35:758-761 |
| ISSN: | 1399-6576 0001-5172 |
| Popis: | Heparin has been suggested as an activator of the plasma kallikrein-kinin system, with possible formation of bradykinin, a potent vasodilator. Haemodynamic effects and changes in the kallikrein-kinin system were studied after heparin- and saline-injections in ten patients undergoing coronary bypass surgery. A moderate decrease in mean arterial pressure was found in all patients in the observation period, but significantly more at 2 and 3 min after heparin-injection compared with saline-injection. None of the other haemodynamic variables measured were significantly different when comparing heparin- to saline-injection. Heparin-injection resulted in significant changes in the kallikrein-kinin system, with a marked increase in spontaneous kallikrein-like activity as the most prominent feature, while no changes were found after saline-injection. Liberation of bradykinin would be expected to give a decrease in systemic vascular resistance with an increase in cardiac output. The results indicate that the plasma kallikrein-kinin system, though apparently activated after heparin-injection, does not contribute significantly to the decrease in arterial pressure in the patients studied. |
| Databáze: | OpenAIRE |
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