Heterozygous carriers of a Parkin or PINK1 mutation share a common functional endophenotype
| Autor: | J. Hagenah, T. van Eimeren, Ferdinand Binkofski, Bastiaan R. Bloem, Peter P. Pramstaller, Katja Lohmann, M. M. Weiss, Kathrin Reetz, B.F.L. van Nuenen, Cliff S. Klein, Hartwig R. Siebner |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Heterozygote Movement Ubiquitin-Protein Ligases Adaptation Biological Context (language use) PINK1 Parkin Premotor cortex 03 medical and health sciences 0302 clinical medicine Parkinsonian Disorders Motor system Perception and Action [DCN 1] medicine Humans Genetic Predisposition to Disease 030304 developmental biology Brain Mapping 0303 health sciences Neuronal Plasticity Supplementary motor area Genetic Carrier Screening Motor Cortex Middle Aged Magnetic Resonance Imaging Frontal Lobe Phenotype medicine.anatomical_structure Frontal lobe nervous system Mutation Female Neurology (clinical) Psychology Protein Kinases Neuroscience Biomarkers 030217 neurology & neurosurgery Motor cortex |
| Zdroj: | Neurology, 72, 1041-7 Neurology, 72, 12, pp. 1041-7 |
| ISSN: | 0028-3878 |
| Popis: | Contains fulltext : 80510.pdf (Publisher’s version ) (Open Access) OBJECTIVE: To use a combined neurogenetic-neuroimaging approach to examine the functional consequences of preclinical dopaminergic nigrostriatal dysfunction in the human motor system. Specifically, we examined how a single heterozygous mutation in different genes associated with recessively inherited Parkinson disease alters the cortical control of sequential finger movements. METHODS: Nonmanifesting individuals carrying a single heterozygous Parkin (n = 13) or PINK1 (n = 9) mutation and 23 healthy controls without these mutations were studied with functional MRI (fMRI). During fMRI, participants performed simple sequences of three thumb-to-finger opposition movements with their right dominant hand. Since heterozygous Parkin and PINK1 mutations cause a latent dopaminergic nigrostriatal dysfunction, we predicted a compensatory recruitment of those rostral premotor areas that are normally implicated in the control of complex motor sequences. We expected this overactivity to be independent of the underlying genotype. RESULTS: Task performance was comparable for all groups. The performance of a simple motor sequence task consistently activated the rostral supplementary motor area and right rostral dorsal premotor cortex in mutation carriers but not in controls. Task-related activation of these premotor areas was similar in carriers of a Parkin or PINK1 mutation. CONCLUSION: Mutations in different genes linked to recessively inherited Parkinson disease are associated with an additional recruitment of rostral supplementary motor area and rostral dorsal premotor cortex during a simple motor sequence task. These premotor areas were recruited independently of the underlying genotype. The observed activation most likely reflects a "generic" compensatory mechanism to maintain motor function in the context of a mild dopaminergic deficit. |
| Databáze: | OpenAIRE |
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