Variation in lumbar spine and femoral neck bone mineral measured by dual energy X-ray absorption: a study of 329 normal women
| Autor: | J G Truscott, M. Simpson, C.F. Westmacott, S. P. Stewart, Richard Milner, Michael A. Smith, A. Horsman, B. Oldroyd |
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| Rok vydání: | 1993 |
| Předmět: |
musculoskeletal diseases
Adult medicine.medical_specialty Bone density Bone and Bones Absorptiometry Photon Bone Density Reference Values Medicine Humans Radiology Nuclear Medicine and imaging Femoral neck Aged Bone mineral Aged 80 and over Postmenopausal women Lumbar Vertebrae Dual energy business.industry Femur Neck General Medicine Middle Aged musculoskeletal system medicine.disease Menopause medicine.anatomical_structure Femur bone Lumbar spine Female Radiology business Nuclear medicine |
| Zdroj: | The British journal of radiology. 66(786) |
| ISSN: | 0007-1285 |
| Popis: | Reference ranges used in dual energy X-ray absorptiometry (DXA) have previously used piecewise linear fits to the whole data set for spine or femur bone mineral density (BMD) as a function of age. In a study of 329 Caucasian normal women we present a refinement to the normal range by fitting straight lines between quinquennial mean values of BMD for each site measured (lumbar spine, femoral neck and Ward's triangle). From the age of 40 years onwards the premenopausal women demonstrated minimal loss of BMD whereas postmenopausal women showed a rapid loss amounting to 27% in the lumbar spine, 27% in the femoral neck and 38% in the Ward's triangle region in the age range under examination. Comparison of quinquennial means for pre and postmenopausal women in age bands 45-49 years and 50-54 years shows that at these ages postmenopausal BMD is significantly lower than premenopausal BMD (P < 0.05). This finding suggests that separate normal ranges should be used for pre and postmenopausal women. As reduction in the production of oestrogen is a major factor in postmenopausal bone loss and oestrogen function is related to years since menopause (YSM), a more logical way of displaying postmenopausal normal BMD ranges would be in terms of YSM rather than chronological age. Such data are given in this paper. |
| Databáze: | OpenAIRE |
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