The development of DT-diaphorase in rat liver and its induction by benzo(a)pyrene
| Autor: | R.S. Everts, H. Havinga, F.A. Hommes |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
Liver cytology
Dehydrogenase chemistry.chemical_compound Cytosol Animals NADH NADPH Oxidoreductases Enzyme inducer Benzopyrenes Quinone Reductases chemistry.chemical_classification biology DNA synthesis Age Factors DNA Rats Enzyme chemistry Biochemistry Benzo(a)pyrene Animals Newborn Liver Enzyme Induction Pediatrics Perinatology and Child Health biology.protein Pyrene RNA NAD+ kinase Developmental Biology |
| Zdroj: | Biology of the neonate. 34(5-6) |
| ISSN: | 0006-3126 |
| Popis: | The development of cytosolic DT-diaphorase – NAD(P)H dehydrogenase, quinone, EC 1.6.99.2 – and its induction by benzo(a)pyrene has been studied in rat liver. DT-diaphorase belongs to the late suckling cluster, because the largest increase in activity can be observed 18 days after birth. A considerable activity is present, however, in the neonatal period. The activity of the enzyme can be prematurely induced by benzo(a)pyrene. A lag phase of 10 h can be observed before the activity of DT-diaphorase starts to increase. This increase in activity proved to be sensitive to inhibitors of mixed-function oxydase and RNA and DNA synthesis. |
| Databáze: | OpenAIRE |
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