25 years after Vi typhoid vaccine efficacy study, typhoid affects significant number of population in Nepal
| Autor: | Mahesh K. Puri, M. Imran Khan, R. Leon Ochiai, Sushant Sahastrabuddhe, Thomas F. Wierzba, Nilesh Joshi, Shyam Raj Upreti, Parisha Shrestha, Deepak Bajracharya, Alfred Pach |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Bacterial Diseases
Veterinary medicine Salmonellosis Sanitation Infectious Disease Control Epidemiology Population lcsh:Medicine Salmonella typhi History 21st Century Microbiology Typhoid fever Infectious Disease Epidemiology Nepal Salmonella Environmental health Epidemic Typhus Prevalence Medicine Humans Typhoid Fever Adverse effect education lcsh:Science Biology Retrospective Studies education.field_of_study Multidisciplinary Population Biology business.industry Incidence (epidemiology) Typhoid-Paratyphoid Vaccines Vaccination lcsh:R Immunity History 20th Century medicine.disease Bacterial Pathogens Infectious Diseases Population Surveillance Typhoid vaccine Clinical Immunology lcsh:Q business Efficacy Study Research Article |
| Zdroj: | PLoS ONE, Vol 9, Iss 1, p e77974 (2014) PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | Salmonella Typhi, first isolated in 1884, results in infection of the intestines and can end in death and disability. Due to serious adverse events post vaccination, whole cell killed vaccines have been replaced with new generation vaccines. The efficacy of Vi polysaccharide (ViPS) vaccine, a new generation, single-dose intramuscular typhoid vaccine was assessed in Nepal in 1987. However, despite the availability of ViPS vaccine for more than 25 years, Nepal has one of the highest incidence of typhoid fever. Therefore we collected information from hospitals in the Kathmandu Valley from over the past five years. There were 9901 enteric fever cases between January 2008 and July 2012. 1,881 of these were confirmed typhoid cases from five hospitals in the Kathmandu district. Approximately 70% of the cases involved children under 15 years old. 1281 cases were confirmed as S. Paratyphi. Vaccines should be prioritized for control of typhoid in conjunction with improved water and sanitation conditions in Nepal and in endemic countries of Asia and Africa. |
| Databáze: | OpenAIRE |
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