Takayasu's arteritis is associated with HLA-B*52, but not with HLA-B*51, in Turkey

Autor: Zeynep Ozbalkan, Yaşar Karaaslan, Izzet Fresko, Nurşen Düzgün, Muge Bicakcigil, Omer Karadag, Nurullah Akkoc, Fatos Onen, Aşkın Ateş, Güher Saruhan-Direskeneli, Veli Cobankara, A. Mesut Onat, Mehmet Akif Ozturk, Gökhan Keser, Neslihan Yilmaz, Emire Seyahi, Haner Direskeneli, Murat Inanc, Sevil Kamali, Ayse Cefle, F. Aytül Uyar, Vuslat Yilmaz, Ziver Sahin, Ercan Tunc, Sibel Zehra Aydin, Servet Akar, Sedat Kiraz, Kenan Aksu, Huseyin T. E. Ozer
Přispěvatelé: Ege Üniversitesi, Çukurova Üniversitesi, Sahin, Ziver, Bicakcigil, Muge, Aksu, Kenan, Kamali, Sevil, Akar, Servet, Onen, Fatos, Karadag, Omer, Ozbalkan, Zeynep, Ates, Askin, Ozer, Huseyin T. E., Yilmaz, Vuslat, Seyahi, Emire, Ozturk, Mehmet A., Cefle, Ayse, Cobankara, Veli, Onat, A. Mesut, Tunc, Ercan, Duzgun, Nursen, Aydin, Sibel Z., Yilmaz, Neslihan, Fresko, Izzet, Karaaslan, Yasar, Kiraz, Sedat, Akkoc, Nurullah, Inanc, Murat, Keser, Gokhan, Uyar, F. Aytul, Direskeneli, Haner, Saruhan-Direskeneli, Guher, Sahin, Z., Bicakcigil, M., Aksu, K., Kamali, S., Akar, S., Onen, F., Saruhan-Direskeneli, G., Yeditepe Üniversitesi
Jazyk: angličtina
Rok vydání: 2012
Předmět:
Male
Turkey
polymerase chain reaction
Takayasu's arteritis
CLINICAL-MANIFESTATIONS
SUSCEPTIBILITY
HLA B52 antigen
Gastroenterology
Turkey (republic)
Pathogenesis
chi square distribution
middle aged
Odds Ratio
Immunology and Allergy
genetics
risk
BEHCETS-DISEASE
aorta arch syndrome
article
genetic screening
HLA-B
female
HLA-B51 Antigen
disease severity
Research Article
Adult
medicine.medical_specialty
GENE POLYMORPHISM
Genotype
HLA B51 antigen
Immunology
DNA determination
Human leukocyte antigen
gene sequence
gene frequency
CLASSIFICATION
ANTIGENS
Rheumatology
GIANT-CELL ARTERITIS
Internal medicine
medicine
Humans
controlled study
Genetic Predisposition to Disease
Arteritis
human
Chi-Square Distribution
business.industry
disease association
Case-control study
Odds ratio
DNA
case control study
medicine.disease
major clinical study
Takayasu Arteritis
MHC CLASS-I
Giant cell arteritis
HLA-B ALLELES
multicenter study
age
Case-Control Studies
business
HLA-B52 Antigen
genetic predisposition
AORTIC TISSUE
genetic susceptibility
Zdroj: Arthritis Research & Therapy
ISSN: 2230-9845
Popis: WOS: 000304698800041
PubMed ID: 22309845
Introduction: HLA-B*51 and HLA-B*52 are two close human leukocyte antigen (HLA) allele groups with minor amino acid differences. However, they are associated with two different vasculitides (HLA-B*51 in Beh et's disease and HLA-B*52 in Takayasu's arteritis (TAK)) and with major clinical and immunological differences. In this study, we aimed to screen a large cohort of TAK patients from Turkey for the presence of HLA-B*51 and HLA-B* 52 as susceptibility and severity factors. Methods: TAK patients (n = 330) followed at a total of 15 centers were included in the study. The mean age of the patients was 37.8 years, and 86% were women. DNA samples from the patients and healthy controls (HC; n = 210) were isolated, and the presence of HLA-B* 51 or HLA-B* 52 was screened for by using PCR with sequence-specific primers. Results: We found a significant association of HLA-B* 52 with TAK (20.9% vs HC = 6.7%, P = 0.000, OR = 3.7, 95% CI = 2.02 to 6.77). The distribution of HLA-B* 51 did not differ between TAK patients and HCs (22.7% vs 24.8%, OR = 0.9, 95% CI = 0.60 to 1.34). The presence of HLA-B* 52 decreased in late-onset patients (> 40 years of age; 12.0%, P = 0.024, OR = 0.43, 95% CI = 0.20 to 0.91). Patients with angiographic type I disease with limited aortic involvement also had a lower presence of HLA-B* 52 compared to those with all other disease subtypes (13.1% vs 26%, P = 0.005, OR = 0.43, 95% CI = 0.23 to 0.78). Conclusions: In this study, the previously reported association of TAK with HLA-B* 52 in other populations was confirmed in patients from Turkey. The functional relevance of HLA-B* 52 in TAK pathogenesis needs to be explored further.
Istanbul (BAP); Marmara University (BAPKO)Marmara University
This study is funded by Istanbul (BAP) and Marmara University (BAPKO) Research Funds. The authors thank G Mumcu for her assistance with statistical analysis.
Databáze: OpenAIRE
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