Myocardial perfusion abnormalities in asymptomatic type 2 diabetic patients
| Autor: | Azu Owunwanne, Abdelhamid H. Elgazzar, Ismet Sarikaya, Ghada Al-Humaidi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
lcsh:Diseases of the circulatory (Cardiovascular) system Single photon emission computed tomography Infarction 030209 endocrinology & metabolism Type 2 diabetes 030204 cardiovascular system & hematology Asymptomatic Nephropathy Coronary artery disease 03 medical and health sciences Myocardial perfusion imaging 0302 clinical medicine Internal medicine Diabetes mellitus medicine Silent myocardial ischemia medicine.diagnostic_test business.industry 99mTc-tetrofosmin Diabetes medicine.disease lcsh:RC666-701 Cardiology Original Article Radiology medicine.symptom business Perfusion |
| Zdroj: | Journal of the Saudi Heart Association, Vol 30, Iss 1, Pp 3-8 (2018) |
| ISSN: | 1016-7315 |
| Popis: | Objective: The prevalence of coronary artery disease (CAD) is high in patients with diabetes. Because ischemia and infarction are often silent in diabetic patients, diagnosis of CAD occurs inevitably late. It is essential to identify the presence of CAD in diabetic patients to start early treatment. Therefore, the aim of this study was to determine the prevalence of abnormal myocardial perfusion in asymptomatic type 2 diabetic patients using myocardial perfusion imaging. Methods: Fifty-nine patients with type 2 diabetes, who did not have any history of CAD, but did have risk factors underwent myocardial perfusion single-photon emission computed tomography (SPECT) imaging using 99mTc-tetrofosmin and a 2-day stress–rest protocol. Two nuclear medicine specialists independently interpreted the images. Statistical analysis was performed to determine if there is a correlation between the presence of perfusion abnormalities and the history of diabetes (duration of disease, type of treatment, level of control, and presence and type of complications). The influence of other factors such as age, sex, smoking history, and family history of CAD, with abnormal scans were also studied. Results: Of the 59 patients, abnormal scans were detected in 22 (37%) including 16 with reversible defects due to stress-induced ischemia. Hence the prevalence was 37%. Duration of diabetes, use of insulin, nephropathy, and neuropathy were significantly associated with abnormal scans (p = 0.048, p = 0.045, p = 0.006, and p = 0.03, respectively). Additionally, positive family history of CAD was highly associated with perfusion abnormalities (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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