New furoquinoline alkaloid and flavanone glycoside derivatives from the leaves ofOricia suaveolens and Oricia renieri(Rutaceae)
| Autor: | Jean Duplex Wansi, James A. S. Howell, Judith Caroline Ngo Nyobe, Luc Mbaze Meva’a, Jean Claude Ndom, Achille Nouga, Alain Njoya, Phillipa B. Cranwell, Laurence M. Harwood, Emmanuel Mpondo Mpondo |
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| Rok vydání: | 2015 |
| Předmět: |
Magnetic Resonance Spectroscopy
Stereochemistry Plant Science Oricia 01 natural sciences Biochemistry Furoquinoline alkaloid Analytical Chemistry chemistry.chemical_compound Carcinoma Cell Humans Organic chemistry Rutaceae chemistry.chemical_classification biology Plant Extracts 010405 organic chemistry Organic Chemistry Glycoside Flavones biology.organism_classification Antineoplastic Agents Phytogenic 0104 chemical sciences Plant Leaves 010404 medicinal & biomolecular chemistry chemistry Quinolines Drug Screening Assays Antitumor Oricia suaveolens Two-dimensional nuclear magnetic resonance spectroscopy Flavanone |
| Zdroj: | Natural Product Research. 30:305-310 |
| ISSN: | 1478-6427 1478-6419 |
| Popis: | Fractionation of the methanol extract of the leaves of Oricia renieri and Oricia suaveolens (Rutaceae) led to the isolation of 13 compounds including the hitherto unknown furoquinoline alkaloid named 6,7-methylenedioxy-5-hydroxy-8-methoxy-dictamnine (1) and a flavanone glycoside named 5-hydroxy-4'-methoxy-7-O-[α-L-rhamnopyranosyl(1‴→5″)-β-D-apiofuranosyl]-flavanoside (2), together with 11 known compounds (3-13). The structures of the compounds were determined by comprehensive analyses of their 1D and 2D NMR, mass spectral data and comparison. All compounds isolated were examined for their activity against human carcinoma cell lines. The alkaloids 1, 5, 12, 13 and the phenolic 2, 8, 11 tested compounds exhibited non-selective moderate cytotoxic activity with IC50 8.7-15.9 μM whereas compounds 3, 4, 6, 7, 9 and 10 showed low activity. |
| Databáze: | OpenAIRE |
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