The dipeptidyl peptidase-4 (DPP-4) inhibitor vildagliptin improves glycemic control in type 2 diabetic patients undergoing hemodialysis
| Autor: | Masayoshi Soma, Kazuyoshi Okada, Masanori Abe, Masaaki Tsuchida, Fumito Kikuchi, Midori Ito, Terumi Higuchi, Hirokazu Sasaki, Noriaki Maruyama |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Pyrrolidines Endocrinology Diabetes and Metabolism Incretin Adamantane Type 2 diabetes Hypoglycemia Gastroenterology Statistics Nonparametric Endocrinology Renal Dialysis Internal medicine Diabetes mellitus Nitriles Medicine Humans Vildagliptin Prospective Studies Dipeptidyl peptidase-4 Glycemic Aged Glycated Hemoglobin Dipeptidyl-Peptidase IV Inhibitors business.industry Middle Aged medicine.disease Postprandial Diabetes Mellitus Type 2 Female business medicine.drug |
| Zdroj: | Endocrine journal. 58(11) |
| ISSN: | 1348-4540 |
| Popis: | The potent and selective dipeptidyl peptidase-4 inhibitor vildagliptin improves glycemic control in patients with type 2 diabetes through incretin hormone-mediated increases in both α- and β-cell responsiveness to glucose. We conducted a prospective, open-label, parallel group, controlled study of 51 patients with type 2 diabetic patients undergoing hemodialysis (HD) during the 24-week study period. Patients were assigned to two groups: the vildagliptin group (n = 30) and the control group (n = 21). Vildagliptin was administered at 50 mg/day for the first 8 weeks. Then doses were titrated by dose-doubling to a maximum of 100 mg/day if hemoglobin A1c (HbA1c) or glycated albumin (GA) target levels had not been reached. No vildagliptin was administered to the controls. The average final dose of vildagliptin was 80 ± 5 mg daily. After 24 weeks, vildagliptin had decreased average HbA1c levels from 6.7 % baseline to 6.1 %, average GA levels from 24.5 % baseline to 20.5 % and average postprandial plasma glucose levels from 186 mg/dL baseline to 140 mg/dL (all p0.0001). In the control group, we observed no such changes. Vildagliptin efficacy did not differ according to age or body mass index, but the GA reduction was significantly greater in the anti-diabetic agents-naïve group. Furthermore, in patients with higher baseline GA levels, a higher vildagliptin dosage was required to produce a noticeable effect. No serious adverse effects such as hypoglycemia or liver impairment were observed in any patient. Vildagliptin was effective as a treatment for diabetic patients undergoing HD. |
| Databáze: | OpenAIRE |
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