CT-derived muscle remodelling after bronchoscopic lung volume reduction in advanced emphysema
| Autor: | Lowie E.G.W. Vanfleteren, Karin J. C. Sanders, Annemie M. W. J. Schols, Karin Klooster, Dirk-Jan Slebos |
|---|---|
| Přispěvatelé: | Pulmonologie, RS: NUTRIM - R3 - Respiratory & Age-related Health, Promovendi NTM, Groningen Research Institute for Asthma and COPD (GRIAC) |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Pulmonary and Respiratory Medicine
Adult Male medicine.medical_specialty SURGERY Respiratory physiology Lung volume reduction surgery Muscle mass Bronchoscopic lung volume reduction 03 medical and health sciences 0302 clinical medicine Internal medicine Bronchoscopy Medicine Humans 030212 general & internal medicine Muscle Skeletal Pneumonectomy Wasting Aged Cross-Over Studies Exercise Tolerance business.industry Skeletal muscle Middle Aged Clinical trial medicine.anatomical_structure PHYSICAL-ACTIVITY 030228 respiratory system Adipose Tissue Pulmonary Emphysema Cardiology Respiratory Mechanics Airway Remodeling SKELETAL-MUSCLE Female Intramuscular fat medicine.symptom business Lung Volume Measurements Tomography X-Ray Computed Follow-Up Studies |
| Zdroj: | Thorax, 74(2), 206-207. BMJ Publishing Group Thorax, 74(2), 206-207. BMJ PUBLISHING GROUP |
| ISSN: | 0040-6376 |
| Popis: | Muscle wasting frequently occurs in severe emphysema. Improving respiratory mechanics by bronchoscopic lung volume reduction using endobronchial valves (EBV) might prevent further loss or even increase in muscle mass. CT-derived skeletal muscle mass gain was observed in 39/49 patients 6 months after EBV. Multiple linear regression showed that gain in muscle (β=2.4; 95% CI 0.2 to 4.6; p=0.036) and intramuscular fat (β=3.1; 95% CI 0.2 to 5.9; p=0.035) is associated with improved 6 min walk distance independent of the change in residual volume. Skeletal muscle remodelling associates with improved exercise capacity after EBV, independent of hyperinflation reduction.Trial registration numberClinical trial registered with the Dutch trial register www.trialregister.nl (NTR2876), Results. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|