Comparative protective immunity provided by live vaccines of Newcastle disease virus or avian metapneumovirus when co-administered alongside classical and variant strains of infectious bronchitis virus in day-old broiler chicks

Autor: Andreas Herrmann, Christopher Ball, Kannan Ganapathy, Stephane Lemiere, Anne Forrester
Rok vydání: 2019
Předmět:
animal structures
Hemagglutination
Newcastle Disease
Broiler chicken
Infectious bronchitis virus
030231 tropical medicine
Newcastle disease virus
Biology
Antibodies
Viral
Vaccines
Attenuated
Newcastle disease
Article
Virus
Serology
03 medical and health sciences
0302 clinical medicine
Immunity
Animals
Avian metapneumovirus
030212 general & internal medicine
Poultry Diseases
General Veterinary
General Immunology and Microbiology
Infectious bronchitis viruses
Public Health
Environmental and Occupational Health
Viral Vaccines
Hemagglutination Inhibition Tests
biology.organism_classification
Avian infectious bronchitis
Virology
Specific Pathogen-Free Organisms
Vaccination
Infectious Diseases
Day-old vaccination
embryonic structures
Molecular Medicine
Metapneumovirus
Coronavirus Infections
Chickens
Zdroj: Vaccine
ISSN: 0264-410X
Popis: This study reports on the simultaneous administration of live NDV or aMPV subtype B vaccines alongside two live IBV (Massachusetts-H120 and 793B-CR88) vaccines in day-old maternal-antibody positive commercial broiler chicks. In the first experiment, chicks were divided into four groups; one unvaccinated and three groups vaccinated with live NDV VG/GA-Avinew, live H120 + CR88, or VG/GA-Avinew + H120 + CR88. In the second experiment, live aMPV subtype B vaccine was used in place of NDV. Clinical signs were monitored daily and oropharyngeal swabs were taken at regular intervals for vaccine virus detection. Blood was collected at 21 dpv for serology. 10 chicks from each group were challenged with virulent strains of M41 or QX or aMPV subtype B. For IBV, after 5 days post challenge (dpc), tracheal ciliary protection was assessed. For aMPV, clinical scores were recorded up to 10 dpc. For NDV, haemagglutination inhibition (HI) antibody titres were assayed as an indicator of protective immunity. In both experiments, ciliary protection for IBV vaccinated groups was maintained above 90%. The protection against virulent aMPV challenge was not compromised when aMPV, H120 and CR88 were co-administered. NDV HI mean titres in single and combined NDV-vaccinated groups remained above the protective titre (>3 log2). Both experiments demonstrated that simultaneous administration of live NDV VG/GA-Avinew or aMPV subtype B alongside H120 and CR88 vaccines does not interfere with protection conferred against NDV, IBV or aMPV.
Databáze: OpenAIRE
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