Effects of Catechol Estrogen Infusions upon Gonadotropin and Prolactin Concentrations in Men*
| Autor: | Harry R. Reiser, D. Lynn Loriaux, Shinzo Kono, Mortimer B. Lipsett, George R. Merriam |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty medicine.drug_class Endocrinology Diabetes and Metabolism Clinical Biochemistry Biochemistry Excretion Catecholamines Endocrinology Internal medicine Urinary catecholamine medicine Humans Dose-Response Relationship Drug Chemistry Biochemistry (medical) Metabolism Estrogens Catechol Prolactin Catechol estrogen Gonadotropin secretion Blood pressure Receptors Estrogen Gonadotropins Pituitary Gonadotropin hormones hormone substitutes and hormone antagonists |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 53:784-789 |
| ISSN: | 1945-7197 0021-972X |
| Popis: | To study the effects of catechol estrogens upon gonadotropin secretion, 2-hydroxyestrone (2-OHE1) and 2-hydroxyestradiol (2-OHE2) were administered iv to young adult men in a range of doses for 4 days. Blood samples were obtained for plasma LH, FSH, and PRL at 20-min intervals for 6 h before and at the end of the infusion period. 2-OHE1 had no effect upon gonadotropins or PRL in doses up to 1.6 mg/day; at 3.2 and 6.6 mg/day, it produced a slight suppression of LH and FSH, with no change in PRL. 2-OHE2 was generally ineffective at 100 micrograms/day, but doses from 200-800 micrograms/day suppressed gonadotropins, without changes in PRL. These infusions elevated 2-OHE1 and 2-OHE2 plasma levels to values comparable to those measured in late pregnancy. There were no associated effects upon blood pressure and only minimal changes in urinary catecholamine excretion. No effects that could be interpreted as antiestrogenic were observed. These results are consistent with the hypothesis that circulating catechol estrogens behave as weak estrogens in men. |
| Databáze: | OpenAIRE |
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