Remission induction with L-asparaginase, vincristine, and prednisone in children with acute nonl ymphoblastic leukemia
| Autor: | John M. Falletta, Wataru W. Sutow, J. Hugh Bryan, Vita J. Land, Samuel K. Morgan, Paul G. Dyment |
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| Rok vydání: | 1976 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty Vincristine Remission Spontaneous Gastroenterology L asparaginase Leukocyte Count Remission induction Prednisone Internal medicine medicine Asparaginase Humans In patient Child Leukemia business.industry medicine.disease Oncology Leukemia Myeloid Acute nonlymphoblastic leukemia Acute Disease Splenomegaly Pediatrics Perinatology and Child Health Toxicity Drug Therapy Combination Female Leukemia Erythroblastic Acute business Hepatomegaly medicine.drug |
| Zdroj: | Medical and Pediatric Oncology. 2:191-198 |
| ISSN: | 1096-911X 0098-1532 |
| DOI: | 10.1002/mpo.2950020209 |
| Popis: | Forty-five children with acute nonlymphoblastic leukemia in relapse received a total of 56 courses of L-asparaginase combined with vincristine and prednisone. The complete remission rate of 40% (12 of 30 trials) in patients resistant to vincristine and prednisone was almost identical to that in children still sensitive to vincristine and prednisone (42%, 11 of 26 trials). The complete remission rate of 38% (14 of 37 exposures) in those children who had not received L-asparaginase previously compared favorably with the complete remission rate in those children who had received prior L-asparaginase (47%, 9 of 19 exposures). Forty-seven of the 56 induction trials were in children with 1 or more remissions and 14 of these were in children with 3 or more prior remissions. Toxicity was minimal. |
| Databáze: | OpenAIRE |
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