Reaction of Astaxanthin with Peroxynitrite
| Autor: | Yukimasa Terada, Aditya Kulkarni, Hideo Etoh, Tsutomu Hayakawa, Takashi Maoka |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
chemistry.chemical_classification
Antioxidant Molecular Structure Chemistry medicine.medical_treatment Organic Chemistry General Medicine Xanthophylls Applied Microbiology and Biotechnology Biochemistry In vitro Analytical Chemistry chemistry.chemical_compound Astaxanthin Peroxynitrous Acid Nitro medicine Organic chemistry Molecular Biology Carotenoid Chromatography High Pressure Liquid Peroxynitrite Biotechnology |
| Zdroj: | Bioscience, Biotechnology, and Biochemistry. 72:2716-2722 |
| ISSN: | 1347-6947 0916-8451 |
| DOI: | 10.1271/bbb.80358 |
| Popis: | The in vitro reactivities of astaxanthin toward peroxynitrite were investigated and the reaction products after scavenging with peroxynitrite were analyzed in order to determine the complete mechanism of this reaction. A series of carotenoids, 13-apo-astaxanthinone (1), 12'-apo-15'-nitroastaxanthinal (2), 12'-apo-astaxanthinal (3), 10'-apo-astaxanthinal (4), 9-cis-14'-s-cis-15'-nitroastaxanthin (5), 14'-s-cis-15'-nitroastaxanthin (6), 13-cis-14'-s-cis-15'-nitroastaxanthin (7), 10'-s-cis-11'-cis-11'-nitroastaxanthin (8), 13,15,13'-tri-cis-15'-nitroastaxanthin (9), 9-cis-astaxanthin (10), and 13-cis-astaxanthin (11), were isolated from the reaction products of carotenoids with peroxynitrite. Our previous studies achieved for the first time the isolation of nitro derivatives from the reaction of astaxanthin with peroxynitrite. Here we identify the major remaining reaction products of this reaction and investigate the stabilities of the nitro astaxanthins. |
| Databáze: | OpenAIRE |
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