Resetting the Adaptive Immune System After Autologous Stem Cell Transplantation: Lessons from Responses to Vaccines
| Autor: | C.M. Jol-van der Zijde, P. A. W. te Boekhorst, NM Wulffraat, Jaak M. Vossen, R. ten Cate, Rogier Q. Hintzen, M.J.D. van Tol, M. M. ten Dam, D. M. C. Brinkman |
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| Přispěvatelé: | Hematology, Pediatrics, Neurology |
| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
Adult
Male autologous stem cell transplantation Adolescent Rabies medicine.medical_treatment Immunology Hematopoietic stem cell transplantation tetanus Transplantation Autologous Article Autoimmune Diseases Autologous stem-cell transplantation Immune system Antigen SDG 3 - Good Health and Well-being medicine Tetanus Toxoid Immunology and Allergy Humans Prospective Studies Child business.industry Toxoid Hematopoietic Stem Cell Transplantation antibody response Middle Aged Acquired immune system vaccination in vitro proliferation Immunity Innate Vaccination Transplantation Treatment Outcome Rabies Vaccines Child Preschool Female business Immunologic Memory |
| Zdroj: | Journal of Clinical Immunology Journal of Clinical Immunology, 27(6), 647-658. Springer New York |
| ISSN: | 1573-2592 0271-9142 |
| Popis: | Autologous stem cell transplantation (ASCT) to treat autoimmune diseases (AID) is thought to reset immunological memory directed against autoantigens. This hypothesis can only be studied indirectly because the exact nature of the pathogenetic autoantigens is unknown in most AID. Therefore, 19 children with juvenile idiopathic arthritis (JIA) or systemic lupus erythematodes (SLE) and 10 adults with multiple sclerosis (MS) were vaccinated with the T-cell-dependent neoantigen rabies and the recall antigen tetanus toxoid after, respectively before, bone marrow harvest. Both vaccinations were repeated after ASCT. All except two of the responders mounted a primary antibody response to rabies after revaccination, and 44% of the responders mounted a primary antibody response to tetanus boost after ASCT. These data show that immunological memory to a neoantigen is lost in most patients with AID after immunoablative pretreatment; however, memory to a recall antigen boosted before bone marrow harvest is only lost in part of the patients. Disease progression was arrested in all patients with JIA/SLE except one, but only in a minority of MS patients. Clinical outcome on a per case basis was not associated with the profile of the immune response toward the vaccination antigens after ASCT. |
| Databáze: | OpenAIRE |
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