Predictors of MERS-CoV infection: A large case control study of patients presenting with ILI at a MERS-CoV referral hospital in Saudi Arabia
| Autor: | Sameeh Ghazal, Saleh A. Aloqiel, Amal M. Mohamed, Talal A. Altuwaijri, Fahad Bafaqeeh, Kamel Aldosari, Sarah H. Alfaraj, Ziad A. Memish, Donna K. McClish, Hamzah A. Mohd, Ahmed M. Alenzi, Marzouqah S. Alanazi |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male 0301 basic medicine Pediatrics medicine.medical_specialty Referral Middle East Respirator Syndrome viruses 030106 microbiology Saudi Arabia Real-Time Polymerase Chain Reaction Article MERS-CoV 03 medical and health sciences 0302 clinical medicine Predictive Value of Tests Internal medicine medicine Humans In patient 030212 general & internal medicine Mortality Respiratory system Referral and Consultation Cross Infection Predictors business.industry X-Rays Mortality rate Public Health Environmental and Occupational Health Case-control study virus diseases Wbc count Middle Aged Thorax respiratory tract diseases Coronavirus Infectious Diseases Case-Control Studies Middle East Respiratory Syndrome Coronavirus Absolute neutrophil count Female Coronavirus Infections business |
| Zdroj: | Travel Medicine and Infectious Disease |
| ISSN: | 1477-8939 |
| DOI: | 10.1016/j.tmaid.2016.09.008 |
| Popis: | Summary Background A case control study to better characterize the clinical features, laboratory, and radiological abnormalities associated with MERS-CoV infection in order to help with early identification of this syndrome from other respiratory infections. Methods Eighty patients admitted to a hospital in Riyadh, diagnosed with MERS-CoV infection based on RT-PCR were matched on age, sex, and the presence of a co-morbid condition on a basis of 1:2 to other patients admitted with respiratory symptoms and tested negative for MERS-CoV on RT-PCR. Results None of the reported MERS-CoV presenting symptoms was significantly associated with being infected with MERS-CoV. On the other hand, WBC count was significantly lower in patients with confirmed MERS-CoV infection (median 5.7 vs 9.3, P: 0.0004). Neutrophil count was as well significantly lower in MERS-CoV patients (median 3.7 vs 6.7, P: 0.0001). Both AST, and ALT values were significantly higher in MERS-CoV infected group (AST median 42 vs 36, P: 0.03, and ALT median 33 vs 28, P: 0.003). Overall our MERS-CoV mortality rate was (10%) below the national figure of (40%). Conclusions None of the presenting symptoms are specific for MERS-CoV infection. And out of all the investigations WBC, neutrophil counts, AST and ALT values have some predictive utility. |
| Databáze: | OpenAIRE |
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