A Novel Modified Hydrated Sodium Calcium Aluminosilicate (HSCAS) Adsorbent Can Effectively Reduce T-2 Toxin-Induced Toxicity in Growth Performance, Nutrient Digestibility, Serum Biochemistry, and Small Intestinal Morphology in Chicks

Autor:	Lv-Hui Sun, Ying Liu, Desheng Qi, Jin-Tao Wei, Ni-Ya Zhang, Kuntan Wu, Mahmoud Mohamed Khalil, Qiang Liu, Jie-Fan Dai, Hua Sun
Rok vydání:	2019
Předmět:	Male Health Toxicology and Mutagenesis Hydrated Sodium Calcium Aluminosilicate lcsh:Medicine Absorption (skin) Intestinal morphology Toxicology medicine.disease_cause Article Eating Animal science Adsorption T-2 toxin Intestine Small medicine Animals Aspartate Aminotransferases Nutrient digestibility broilers Toxin Chemistry lcsh:R Alanine Transaminase modified HSCAS Blood Proteins Nutrients Liver Serum biochemistry Dietary Supplements Toxicity Aluminum Silicates Digestion Chickens absorption
Zdroj:	Toxins, Vol 11, Iss 4, p 199 (2019) Toxins Volume 11 Issue 4
ISSN:	2072-6651
DOI:	10.3390/toxins11040199
Popis:	The objective of this study was to evaluate the ability of a modified hydrated sodium calcium aluminosilicate (HSCAS) adsorbent to reduce the toxicity of T-2 toxin in broilers. Ninety-six one-day-old male broilers were randomly allocated into four experimental groups with four replicates of six birds each. The four groups, 1&ndash 4, received a basal diet (BD), a BD plus 6.0 mg/kg T-2 toxin, a BD plus 6.0 mg/kg T-2 toxin with 0.05% modified HSCAS adsorbent, and a BD plus 0.05% modified HSCAS adsorbent, respectively, for two weeks. Growth performance, nutrient digestibility, serum biochemistry, and small intestinal histopathology were analyzed. Compared to the control group, dietary supplementation of T-2 toxin decreased (p < 0.05) body weight gain, feed intake, and the feed conversion ratio by 11.4%&ndash 31.8% during the whole experiment. It also decreased (p < 0.05) the apparent metabolic rates of crude protein, calcium, and total phosphorus by 14.9%&ndash 16.1%. The alterations induced by T-2 toxin were mitigated (p < 0.05) by the supplementation of the modified HSCAS adsorbent. Meanwhile, dietary modified HSCAS adsorbent supplementation prevented (p < 0.05) increased serum aspartate aminotransferase by T-2 toxin at d 14. It also prevented (p < 0.05) T-2 toxin-induced morphological changes and damage in the duodenum, jejunum, and ileum of broilers. However, dietary supplementation of the modified HSCAS adsorbent alone did not affect (p > 0.05) any of these variables. In conclusion, these findings indicate that the modified HSCAS adsorbent could be used against T-2 toxin-induced toxicity in growth performance, nutrient digestibility, and hepatic and small intestinal injuries in chicks.
Databáze:	OpenAIRE
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