Fabrication of microcapsules with core‐shell structure for oral delivery of dual drugs and real‐time computed tomography imaging
| Autor: | Fengyi Du, Lulu Zhao, Rong Cai, Miaomiao Zhang, Long Xiao, Jingjing Zhang, Zhirong Wang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Drug Carriers
Fabrication Materials science medicine.diagnostic_test Administration Oral Computed tomography Capsules digestive system diseases Electronic Optical and Magnetic Materials Nanoclusters Core shell Clinical Practice Original Research Paper medicine Digestive tract Electrical and Electronic Engineering Particle Size Drug carrier Tomography X-Ray Computed Original Research Papers TP248.13-248.65 Therapeutic strategy Biomedical engineering Biotechnology |
| Zdroj: | IET Nanobiotechnology IET Nanobiotechnology, Vol 15, Iss 7, Pp 619-626 (2021) |
| ISSN: | 1751-875X 1751-8741 |
| Popis: | Although multidrug combinations are an effective therapeutic strategy for serious disease in clinical practice, their therapeutic effect may be reduced because they conflict with each other medicinally in certain cases. Hence, there is an urgent need to develop a single drug carrier for precise multidrug delivery to avoid this interference. A reverse coordination method is reported that fabricates a double‐layer barium sulphate microcapsule (DL@BS MS) for two drugs separately loading simultaneously. In addition, BS nanoclusters were synthesised in situ inside the DL@BS MSs for real‐time computed tomography (CT) imaging. The results showed that the DL@BS MSs with a particle size of approximately 2 mm exhibited a uniform sphere. Because BS nanoclusters have a high X‐ray attenuation coefficient, the retention of DL@BS MSs in the digestive tract could be monitored through CT imaging in real time. More important, the core‐shell structure of DL@BS MSs encapsulating two different drugs could be released in spatiotemporal order in an acidic stomach environment. The as‐synthesis DL@BS MSs with a core‐shell structure and real‐time imaging performance provide an ideal carrier for the oral administration of multiple drugs simultaneously loaded but sequentially released. |
| Databáze: | OpenAIRE |
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