The NR4A nuclear receptor family in eosinophils
| Autor: | Ryoichi Hashida, Naganari Ohkura, Gozoh Tsujimoto, Hirohisa Saito |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Transcriptional Activation
Receptors Steroid CD30 Nerve growth factor IB Receptors Cytoplasmic and Nuclear Apoptosis Biology Models Biological Dermatitis Atopic Transactivation Anti-Allergic Agents Nuclear Receptor Subfamily 4 Group A Member 2 Nuclear Receptor Subfamily 4 Group A Member 1 Genetics medicine Animals Humans Receptor Genetics (clinical) Eosinophil Neuron-derived orphan receptor 1 DNA-Binding Proteins Eosinophils medicine.anatomical_structure Nuclear receptor Immunology Trans-Activators Signal Transduction Transcription Factors |
| Zdroj: | Journal of Human Genetics. 52:13-20 |
| ISSN: | 1435-232X 1434-5161 |
| DOI: | 10.1007/s10038-006-0085-2 |
| Popis: | It is well-known that many members of the family of nuclear receptors have been implicated in human diseases, and metabolic disorders in particular. The NR4A nuclear receptor family consists of three members, Nur77, Nurr1, and NOR1. All of these are orphan receptors, and Nur77 and NOR1 exert possible pathological roles in immune diseases through the modulation of leukocyte functions. CD30 stimulation, which induces eosinophil-specific apoptosis, markedly enhances expression of Nur77 and NOR1 in eosinophils. This suggests the possibility of pharmacological modulation of Nur77- or NOR1-specific apoptotic pathways via receptor-dependent transactivation. In this review, we discuss treatment of allergic diseases by low molecular weight compounds acting through the NR4A receptor family to cause eosinophil apoptosis. NR4A nuclear receptor genes were selected following comprehensive analysis of differentially expressed genes in eosinophils of atopic dermatitis patients compared with healthy volunteers. |
| Databáze: | OpenAIRE |
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