Brain aluminium accumulation and oxidative stress in the presence of calcium silicate dental cements

Autor: Z Öncel Torun, B Can Demirdöğen, E Çırak, Yaşar Meriç Tunca, Onur Erdem, Kadriye Demirkaya
Přispěvatelé: TOBB ETU, Faculty of Engineering, Department of Biomedical Engineering, TOBB ETÜ, Mühendislik Fakültesi, Biyomedikal Mühendisliği Bölümü, Can Demirdöğen, Birsen
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Male
Antioxidant
Health
Toxicology and Mutagenesis
medicine.medical_treatment
Dental Cements
Toxicology
medicine.disease_cause
chemistry.chemical_compound
0302 clinical medicine
Tooth Socket
Aluminum Compounds
glutathione peroxidase
chemistry.chemical_classification
mineral trioxide aggregate
biology
Chemistry
Glutathione peroxidase
catalase
biomaterial
Brain
Oxides
General Medicine
Catalase
superoxide dismutase
Drug Combinations
tbars
Calcium silicate
Mineral trioxide aggregate
Thiobarbituric Acid Reactive Substances
Superoxide dismutase
Andrology
03 medical and health sciences
Dental cement
medicine
TBARS
Animals
Rats
Wistar
Glutathione Peroxidase
Superoxide Dismutase
Silicates
aluminium
Metallurgy
030206 dentistry
Calcium Compounds
dental cement
Oxidative Stress
endodontics
biology.protein
030217 neurology & neurosurgery
Oxidative stress
Aluminum
Popis: Mineral trioxide aggregate (MTA) is a calcium silicate dental cement used for various applications in dentistry. This study was undertaken to test whether the presence of three commercial brands of calcium silicate dental cements in the dental extraction socket of rats would affect the brain aluminium (Al) levels and oxidative stress parameters. Right upper incisor was extracted and polyethylene tubes filled with MTA Angelus, MTA Fillapex or Theracal LC, or left empty for the control group, were inserted into the extraction socket. Rats were killed 7, 30 or 60 days after operation. Brain tissues were obtained before killing. Al levels were measured by atomic absorption spectrometry. Thiobarbituric acid reactive substances (TBARS) levels, catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities were determined using spectrophotometry. A transient peak was observed in brain Al level of MTA Angelus group on day 7, while MTA Fillapex and Theracal LC groups reached highest brain Al level on day 60. Brain TBARS level, CAT, SOD and GPx activities transiently increased on day 7 and then returned to almost normal levels. This in vivo study for the first time indicated that initial washout may have occurred in MTA Angelus, while element leaching after the setting is complete may have taken place for MTA Fillapex and Theracal LC. Moreover, oxidative stress was induced and antioxidant enzymes were transiently upregulated. Further studies to search for oxidative neuronal damage should be done to completely understand the possible toxic effects of calcium silicate cements on the brain.
Databáze: OpenAIRE
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