The relationship between depression and metabolic control parameters in type 2 diabetic patients: A cross‐sectional and feasibility interventional study
| Autor: | Khalid A. Kheirallah, Abdallah Alzoubi, Dania Abu-Naser, Aws Khasawneh, Adi H Khassawneh, Nour Abdo, Abdel-Hameed Al-Mistarehi, Malak F Albattah |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
endocrine system diseases Cross-sectional study Context (language use) 030204 cardiovascular system & hematology law.invention 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law Internal medicine Diabetes mellitus mental disorders medicine Humans Escitalopram 030212 general & internal medicine Depression (differential diagnoses) Jordan Depression business.industry General Medicine medicine.disease Cross-Sectional Studies Diabetes Mellitus Type 2 Metabolic control analysis Feasibility Studies Metabolic syndrome business medicine.drug |
| Zdroj: | International Journal of Clinical Practice. 75 |
| ISSN: | 1742-1241 1368-5031 |
| DOI: | 10.1111/ijcp.13777 |
| Popis: | Background Substantial evidence supports a bidirectional relationship between diabetes and clinical depression. However, little is known about the effect of treating one condition on the control of the other. Thus, this study aimed to determine the prevalence of depression among Type II diabetes mellitus (T2DM) patients and to assess the efficacy and feasibility of escitalopram treatment of depression on their metabolic control parameters. Methods T2DM patients attending primary care clinics in the North of Jordan were enrolled in a cross-sectional study during the period from February to December 2019 (n = 157). Depressive symptoms were screened utilising the patient health questionnaire-9 (PHQ-9) tool. Metabolic control was assessed by measurement of glycated haemoglobin (HbA1c), triglycerides, cholesterol, low-density lipoprotein (LDL) and high-density lipoprotein (HDL). Patients with moderate to severe depressive symptoms by PHQ-9 (n = 58) were interviewed by a psychiatrist to confirm a clinical diagnosis of depression. Eligible depressed patients were administered escitalopram 10 mg orally once daily for 3 months (n = 12). Thereafter, depressive symptoms and metabolic control measures were reassessed. Results The prevalence of moderate to severe depressive symptoms among T2DM patients, according to PHQ-9, was 36.94%, while the prevalence of clinical depression based on interview was 7.64%. Baseline PHQ-9 scores correlated significantly with baseline levels of HbA1c, HDL, cholesterol and triglycerides. Escitalopram treatment intervention resulted in significant improvement of PHQ-9 scores without significantly improving any of the metabolic control measures. Conclusion The relationship between depression and T2DM in the context of metabolic syndrome is plausible. However, our results show that escitalopram treatment may not be associated with significant improvement in metabolic control parameters among these patients. Our study has laid the groundwork for future randomised clinical trials with larger sample size and longer follow-up. |
| Databáze: | OpenAIRE |
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