Fluoxetine-induced neurotoxicity at environmentally relevant concentrations in adult zebrafish Danio rerio

Autor:	José Manuel Orozco-Hernández, Leobardo Manuel Gómez-Oliván, Gustavo Axel Elizalde-Velázquez, Karina Elisa Rosales-Pérez, Jesús Daniel Cardoso-Vera, Gerardo Heredia-García, Hariz Islas-Flores, Sandra García-Medina, Marcela Galar-Martínez
Rok vydání:	2022
Předmět:	Oxidative Stress Fluoxetine General Neuroscience Acetylcholinesterase Animals Toxicology Water Pollutants Chemical Zebrafish
Zdroj:	NeuroToxicology. 90:121-129
ISSN:	0161-813X
Popis:	Fluoxetine (FLX) exerts its therapeutic effect by inhibiting the presynaptic reuptake of the neurotransmitter serotonin. Nonetheless, at high concentrations of this drug, adverse effects occur in the brain of exposed organisms. Bearing this into account, the objective of this study was to evaluate the neurotoxic effects of the fluoxetine through the evaluation of behavior (Novel tank test), determination of oxidative stress, and determination of acetylcholinesterase (AChE) activity in adult zebrafish Danio rerio. For this purpose, Danio rerio adults were exposed to three environmentally relevant concentrations (5, 10, 16 ng L
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::848c960cb3d455eeedb1ead3dd19a7a9 https://doi.org/10.1016/j.neuro.2022.03.007 Zobrazit plný text záznamu Full Text from ScienceDirect