Acute toxicity of manganese in goldfish Carassius auratus is associated with oxidative stress and organ specific antioxidant responses
| Autor: | Antonio Canalejo, Rafael Torronteras, Francisco Córdoba, Maria Conceiçao Vieira |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Gills
Lipid Peroxides medicine.medical_specialty Antioxidant Health Toxicology and Mutagenesis medicine.medical_treatment Kidney medicine.disease_cause Lipid peroxidation Superoxide dismutase chemistry.chemical_compound Goldfish Internal medicine medicine Animals chemistry.chemical_classification Manganese biology Superoxide Dismutase Glutathione peroxidase Public Health Environmental and Occupational Health Brain Kidney metabolism General Medicine Catalase Pollution Acute toxicity Oxidative Stress Endocrinology Liver Biochemistry chemistry biology.protein Water Pollutants Chemical Oxidative stress |
| Zdroj: | Ecotoxicology and Environmental Safety. 78:212-217 |
| ISSN: | 0147-6513 |
| DOI: | 10.1016/j.ecoenv.2011.11.015 |
| Popis: | Manganese is a relatively common, yet poorly studied element in freshwater ecosystems, where it can be significantly bioconcentrated. The knowledge about the mechanisms of Mn toxicity on fish health is still limited. The aim of the present study was to assess the potential induction of oxidative stress and the antioxidant response after a 96 h waterborne Mn-exposure (at 0.1 and 1mM) in gill, kidney, liver and brain of goldfish (Carassius auratus). Mn 1mM induced an increase of lipid hydroperoxides, superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities in all tissues with the exception of SOD inhibition in the brain. Particular response of catalase (CAT) was indicated-its inhibition in the liver and kidney, but activation in the gill. Exposure to Mn 0.1mM provoked most prominent changes in the liver and did not change the indexes in brain. These results strongly suggest that Mn exposure caused a generalized oxidative stress in the fish and revealed an organ specific antioxidant response involving a differential modulation of the SOD, CAT and GPx activities. |
| Databáze: | OpenAIRE |
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