SCFSlmb E3 ligase-mediated degradation of Expanded is inhibited by the Hippo pathway in Drosophila
| Autor: | Renjie Jiao, Changqing Li, Hanqing Chen, Hongtao Zhang, Wen Dui, Fei Dai, Chuanxian Wei, Honggang Wu, Wu-Min Deng |
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| Rok vydání: | 2014 |
| Předmět: |
endocrine system
animal structures Protein Serine-Threonine Kinases Bioinformatics Cell Line Ubiquitin Transcription (biology) Animals Drosophila Proteins Protein Interaction Maps Molecular Biology Hippo signaling pathway SKP Cullin F-Box Protein Ligases biology fungi Intracellular Signaling Peptides and Proteins Ubiquitination Membrane Proteins Cell Biology Ubiquitin ligase Cell biology body regions Hippo signaling Cell culture Proteolysis biology.protein Original Article Drosophila sense organs Signal transduction Protein Kinases Homeostasis Signal Transduction |
| Zdroj: | Cell Research. 25:93-109 |
| ISSN: | 1748-7838 1001-0602 |
| Popis: | Deregulation of the evolutionarily conserved Hippo pathway has been implicated in abnormal development of animals and in several types of cancer. One mechanism of Hippo pathway regulation is achieved by controlling the stability of its regulatory components. However, the executive E3 ligases that are involved in this process, and how the process is regulated, remain poorly defined. In this study, we identify, through a genetic candidate screen, the SCF(Slmb) E3 ligase as a novel negative regulator of the Hippo pathway in Drosophila imaginal tissues via mediation of the degradation of Expanded (Ex). Mechanistic study shows that Slmb-mediated degradation of Ex is inhibited by the Hippo signaling. Considering the fact that Hippo signaling suppresses the transcription of ex, we propose that the Hippo pathway employs a double security mechanism to ensure fine-tuned homeostasis during development. |
| Databáze: | OpenAIRE |
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