The effects of smoking on corneal endothelial cells: a cross-sectional study on a population from Isfahan, Iran
| Autor: | Ali Salehi, Hamidreza Jahanbani-Ardakani, Mohammad-Ali Abtahi, Khodayar Golabchi, Ziba Farajzadegan, Sara Ghaffari |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty genetic structures Cross-sectional study Population Cell Count Iran Toxicology Cell size 03 medical and health sciences 0302 clinical medicine Ophthalmology Cornea Cell density medicine Humans education Aged Cell Size education.field_of_study business.industry Endothelium Corneal Smoking Endothelial Cells Mean age General Medicine Tobacco Use Disorder Middle Aged eye diseases Oxidative Stress 030104 developmental biology medicine.anatomical_structure Cross-Sectional Studies SPECULAR MICROSCOPY 030221 ophthalmology & optometry Corneal endothelial cell Female sense organs business |
| Zdroj: | Cutaneous and ocular toxicology. 37(1) |
| ISSN: | 1556-9535 |
| Popis: | The aim of this study is to compare the effect of smoking in corneal endothelial cell number and morphology by specular microscopy on a non-smoker population.Our cross-sectional study was performed on 150 participants from a non-smoker population. Non-contact specular microscopy (Tomey Corporation Inc., Nagoya, Japan) was performed in the center of the cornea of all subjects. The cell density (CD), average cell size (AVG), percent of hexagonality (HEX%) and central corneal thickness (CCT) were calculated and compared in both groups.Totally, 76 eyes of 76 smokers and 74 eyes of 74 non-smokers were enrolled in the study from 2015 to 2016. The mean age of smokers and non-smokers were 48.61 ± 17.04 and 46.39 ± 13.02, respectively. The mean number of pack/year among the smokers was 17.36 ± 14.68. Also, the mean values of AVG and CD were significantly different for these two groups (p = 0.011 and p = 0.039, respectively). Other corneal endothelial variables did not show a significant difference between smokers and non-smokers (p 0.05). However, smokers with severe nicotine dependency had significantly greater AVG and lower CD in comparison with the non-smokers (p = 0.004 and p = 0.013, respectively).Our study showed that smoking can cause significant changes in some of the corneal endothelial variables, but not all of them. |
| Databáze: | OpenAIRE |
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