Helicobacter pyloriand risk of upper gastrointestinal bleeding among users of selective serotonin reuptake inhibitors
| Autor: | Mette Wildner-Christensen, Jesper Hallas, Ove B. Schaffalitzky de Muckadell, Jane Møller Hansen, Annmarie Touborg Lassen, Michael Dall |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Peptic Ulcer medicine.medical_specialty Population behavioral disciplines and activities Risk Assessment Gastroenterology Helicobacter Infections Risk Factors Internal medicine mental disorders Odds Ratio Humans Medicine Medical history education Aged education.field_of_study Helicobacter pylori biology business.industry digestive oral and skin physiology Case-control study Odds ratio Middle Aged biology.organism_classification medicine.disease Case-Control Studies Gastritis Serotonin Uptake Inhibitors Female Upper gastrointestinal bleeding medicine.symptom Gastrointestinal Hemorrhage business Risk assessment Selective Serotonin Reuptake Inhibitors |
| Zdroj: | Dall, M, Schaffalitzky de Muckadell, O B, Møller Hansen, J, Wildner-Christensen, M, Touborg Lassen, A & Hallas, J 2011, ' Helicobacter pylori and risk of upper gastrointestinal bleeding among users of selective serotonin reuptake inhibitors ', Scandinavian Journal of Gastroenterology, vol. 46, no. 9, pp. 1039-44 . https://doi.org/10.3109/00365521.2011.580100 |
| ISSN: | 1502-7708 0036-5521 |
| DOI: | 10.3109/00365521.2011.580100 |
| Popis: | A number of studies have reported a possible association between use of selective serotonin reuptake inhibitors (SSRIs) and serious upper gastrointestinal bleeding (UGB). We conducted this case-control study to assess if Helicobacter pylori (H. pylori) potentiates the risk of serious UGB in SSRI users.A population-based case-control study was conducted in the county of Funen, Denmark. Cases were 53 SSRI users with serious UGB whose H. pylori status on their bleeding date could be established. Controls (n = 723) were selected among subjects who participated in a population H. pylori screening study, and who were users of SSRIs. Data on drug exposure and medical history were retrieved from a prescription database and the county's patient register. Confounders were controlled for by unconditional logistic regression.H. pylori infection increased the risk of serious UGB in patients using SSRI with an adjusted odds ratio (OR) of 2.73 (95% confidence interval (CI), 1.17-6.36). The adjusted OR for serious UGB among users of non-steroidal anti-inflammatory drugs (NSAIDs) and acetylsalicylic acid (ASA) were 3.91 (95% CI, 2.03-7.52) and 3.00 (95% CI, 0.94-9.54), respectively.H. pylori infection increases the risk of SSRI-related serious UGB. |
| Databáze: | OpenAIRE |
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