Alkaloids from the Leaves of Annona crassiflora and Their Cytotoxic Activity
| Autor: | Marcelo J. P. Ferreira, Deborah Yara Alves Cursino dos Santos, Miguel Peña-Hidalgo, Luciana Costa Furtado, Letícia V. Costa-Lotufo |
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| Rok vydání: | 2021 |
| Předmět: |
CITOTOXINAS
biology Traditional medicine 010405 organic chemistry Alkaloid Annona crassiflora Aporphines biology.organism_classification 01 natural sciences 0104 chemical sciences Magnoliids 010404 medicinal & biomolecular chemistry chemistry.chemical_compound chemistry Annonaceae Anonaine Aporphine General Pharmacology Toxicology and Pharmaceutics Annona |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 1981-528X |
| DOI: | 10.1007/s43450-021-00147-4 |
| Popis: | Aporphines are a class of alkaloids mostly reported in Magnoliids. The genus Annona, Annonaceae, presents great structural diversity of these compounds. Chemical investigation of leaves from Annona crassiflora Mart. resulted in the identification of an undescribed aporphine alkaloid, which was named as crassiflorine, in addition to six known analogues: anonaine, annoretine, xylopine, tetrahydropalmatrubine, litseglutine B, and stephalagine. The structure of crassiflorine was established through 1D and 2D NMR data in combination with HREIMS and IR analyses. The cytotoxic activity for all tested compounds was marginal (IC50 > 30 μM) against breast carcinoma (MCF-7) and colorectal carcinoma (HCT-116) cell lines. |
| Databáze: | OpenAIRE |
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