Expression of a disintegrin and metalloproteinase-33 protein in vocal fold polyps
| Autor: | Ozgul Topal, Hilal Erinanc, Selim S. Erbek, M V Akdogan |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Stromal cell Adolescent Disintegrins Vocal Cords Laryngeal Diseases Pathogenesis Young Adult Polyps Stroma otorhinolaryngologic diseases medicine Humans Aged Metalloproteinase business.industry Reflux General Medicine Middle Aged Immunohistochemistry Staining ADAM Proteins Otorhinolaryngology Female business Immunostaining |
| Zdroj: | The Journal of Laryngology & Otology. 129:688-692 |
| ISSN: | 1748-5460 0022-2151 |
| Popis: | Background:This study aimed to evaluate the association of a disintegrin and metalloproteinase-33 protein (‘ADAM-33’) expression in vocal polyp formation and to determine its correlation with clinical characteristics.Methods:Medical charts and histological sections of 32 patients diagnosed with vocal polyps who underwent surgery were analysed. Controls were histopathologically normal vocal fold tissues obtained from 36 patients who underwent surgery for laryngeal squamous cell carcinoma. Immunohistochemical staining was performed to detect ADAM-33 expression in epithelial cells, stroma and vessels.Results:All epithelial, stromal and vascular staining scores were significantly greater in polyp tissue than in controls (p p p = 0.05).Conclusion:In this study, ADAM-33 immunostaining was significantly increased in vocal polyps. Therefore, over-expression of this protein may be associated with vocal polyp pathogenesis. |
| Databáze: | OpenAIRE |
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