Potential role of LMP2 as an anti-oncogenic factor in human uterine leiomyosarcoma: Morphological significance of calponin h1
| Autor: | Akiko Horiuchi, Nobuyoshi Hiraoka, Osamu Ishiko, Takuma Hayashi, Kenji Sano, Tomoyuki Ichimura, Tanri Shiozawa, Hiroyuki Aburatani, Nobuo Yaegashi, Yae Kanai, Tamotsu Sudo, Mari Kasai, Ikuo Konishi, Ryuichiro Nishimura |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Adult
Leiomyosarcoma medicine.medical_specialty Biophysics Biology Cell morphology medicine.disease_cause Biochemistry Calponin-h1 Malignant transformation Mice Structural Biology Internal medicine Uterine leiomyosarcoma Genetics medicine otorhinolaryngologic diseases Animals Humans LMP2 Molecular Biology Aged Aged 80 and over Smooth Muscle Neoplasm Myometrium Cell Biology Middle Aged Calponin h1 Cysteine Endopeptidases stomatognathic diseases Cell Transformation Neoplastic Endocrinology Proteasome Uterine Neoplasms Cancer research Female Carcinogenesis |
| Zdroj: | FEBS LETTERS. 586(13):1824-1831 |
| ISSN: | 0014-5793 |
| Popis: | Uterine leiomyosarcoma (LMS) is a highly metastatic smooth muscle neoplasm for which calponin h1 is suspected to have a biological role as a tumor-suppressor. We earlier reported that LMP2-null mice spontaneously develop uterine LMS through malignant transformation of the myometrium, thus implicating this protein as an anti-tumorigenic candidate as well. In the present study, we show that LMP2 may negatively regulate LMS independently of its role in the proteasome. Moreover, several lines of evidence indicate that although calponin h1 does not directly influence tumorigenesis, it clearly affects LMP2-induced cellular morphological changes. Modulation of LMP2 may lead to new therapeutic approaches in human uterine LMS. Article FEBS LETTERS. 586(13):1824-1831 (2012) |
| Databáze: | OpenAIRE |
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