Synthesis andIn‐VitroAntibacterial Activity of 5‐Substituted 1‐Methyl‐4‐nitro‐1H‐imidazoles
| Autor: | Ali Asadipour, Alireza Aliabadi, Alireza Foroumadi, Negar Mohammadhosseini, Bahram Letafat, Abbas Shafiee, Mohammad Hassan Moshafi, Saeed Emami |
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| Rok vydání: | 2008 |
| Předmět: |
biology
Colony Count Microbial Pharmaceutical Science Microbial Sensitivity Tests Bacillus subtilis Gram-Positive Bacteria biology.organism_classification medicine.disease_cause Enterobacter aerogenes medicine.disease Anti-Bacterial Agents Microbiology Structure-Activity Relationship Nitroimidazoles Staphylococcus epidermidis Staphylococcus aureus Gram-Negative Bacteria Drug Discovery medicine Klebsiella pneumonia Antibacterial activity Escherichia coli Bacteria |
| Zdroj: | Archiv der Pharmazie. 341:497-501 |
| ISSN: | 1521-4184 0365-6233 |
| DOI: | 10.1002/ardp.200800022 |
| Popis: | A series of 5-substituted 1-methyl-4-nitro-1H-imidazole derivatives were synthesized and evaluated for in-vitro antibacterial activity against a panel of microorganisms including Staphylococcus aureus, Staphylococcus epidermidis, Bacillus subtilis, Escherichia coli, Klebsiella pneumonia, Enterobacter aerogenes, and Helicobacter pylori using conventional agar dilution method. Among the test compounds, 1-methyl-4-nitro-5-(phenylsulfonyl)-1H-imidazole was the most potent against Gram-positive bacteria, with a MIC value of < or =8 microg/mL. All compounds showed no significant activity against Gram-negative bacteria at concentrations < or =64 microg/mL. The MIC values against 15 clinical isolates of H. pylori indicated that compounds 10 and 11 were the most active compounds in this series in terms of inhibiting the growth of H. pylori (MIC = 2 microg/mL). It was also demonstrated that their corresponding activities were four times larger than that of metronidazole. |
| Databáze: | OpenAIRE |
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