Influence of sonication and in vitro evaluation of nifedipine self-nanoemulsifying drug delivery system
| Autor: | Ahmad M. Eid, Nidal Jaradat, Nagib Ali Elmarzugi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Materials science
Chromatography Nifedipine Scanning electron microscope Sonication 030226 pharmacology & pharmacy 01 natural sciences Self nanoemulsifying 0104 chemical sciences RS1-441 010404 medicinal & biomolecular chemistry 03 medical and health sciences 0302 clinical medicine Pharmacy and materia medica Drug delivery SEM medicine Zeta potential Ternary phase diagram Particle size Self-nanoemulsifying drug delivery system medicine.drug |
| Zdroj: | Brazilian Journal of Pharmaceutical Sciences, Vol 55 (2019) Brazilian Journal of Pharmaceutical Sciences; Vol. 55 (2019); e17497 Brazilian Journal of Pharmaceutical Sciences; v. 55 (2019); e17497 Brazilian Journal of Pharmaceutical Sciences Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 2175-9790 1984-8250 |
| Popis: | In order to develop a self-nanoemulsifying system, three components, olive oil, Tween 80, and Capmul, were used to construct a ternary phase diagram that helped to find the optimum formulation, which was loaded with nifedipine. The effect of sonication on drug loading was also evaluated. After that, measurement of the droplet size, size distribution, zeta potential, and scanning electron microscopy were conducted for evaluation and characterisation of the formulations. The phase diagram of four formulations showed nanosizes below 200 nm; however, only one was selected to be loaded with nifedipine. The selected formulation had the lowest droplet size of 98 nm and size distribution 0.192, and was composed of 48% Tween 80, 32% Capmul, and 20% olive oil. The nifedipine self-nanoemulsifying drug delivery system (SNEDDS) showed a significant change in the particle size (97 nm) and size distribution (0.257) after sonication. Its zeta potential was -32.3 mV indicating good stability. The SEM photographs of nifedipine showed particles with spherical shape and smooth surface. Finally, a self-nanoemulsifying formulation containing nifedipine, loaded in olive oil, was successfully prepared by mixing the oil with various types of surfactants and co-surfactants. A significant nifedipine self-nanoemulsifying system was developed and significantly improved accordingly. |
| Databáze: | OpenAIRE |
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