The role of SOX2 overexpression in prognosis of patients with solid tumors: A meta-analysis and system review
| Autor: | Tujin Wu, Shengjie Wang, Lin Xu, Guangwen Sun, Xiaozhen Zhan, Bing Chen, Songling Yan, Ying Chen, Xinli Liu |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Oncology
medicine.medical_specialty Multivariate analysis SOX2 03 medical and health sciences 0302 clinical medicine Internal medicine Neoplasms medicine Biomarkers Tumor Humans 030212 general & internal medicine Survival analysis Proportional Hazards Models Univariate analysis Proportional hazards model business.industry SOXB1 Transcription Factors Hazard ratio Univariate General Medicine Prognosis Survival Analysis Confidence interval Gene Expression Regulation Neoplastic meta-analysis 030220 oncology & carcinogenesis Meta-analysis solid tumor business Systematic Review and Meta-Analysis Research Article |
| Zdroj: | Medicine |
| ISSN: | 1536-5964 |
| Popis: | Background: Many studies have been done to reported the value of SRY-related HMG-box Gene 2 (SOX2) in prognosis of solid tumors. But results were not particularly consistent among these studies because of the limitations of the small sample data. Methods: We searched relevant studies published before November 2018 by PubMed, Web of Science and EMBASE. In this meta-analysis, hazard ratio (HR) values for overall survival (OS) were cumulatively pooled and quantitatively analyzed. Results: A meta-analysis based on 12 studies with 3318 patients was conducted to assess the potential correlation between SOX2 overexpression and OS in human solid tumors. A total of 12 studies (n = 3318) were assessed in the meta-analysis. It suggested that the high expression of SOX2 obviously indicates poor survival and prognosis in both univariate and multivariate analysis. In the univariate analysis, the combined HR for OS was 1.66 (95% confidence interval [CI]: 1.46–1.89, P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|