CD30 expression by CD8+ T cells producing type 2 helper cytokines. Evidence for large numbers of CD8+CD30+ T cell clones in human immunodeficiency virus infection
| Autor: | Fabrizio Vinante, Mg Giudizi, Paola Parronchi, L Giannarini, Roberta Biagiotti, S. Sampognaro, Francesco Annunziato, Enrico Maggi, Roberto Manetti, Giovanni Pizzolo, Sergio Romagnani, Mp Piccinni |
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| Rok vydání: | 1994 |
| Předmět: |
Interferon type II
T cell Immunology Ki-1 Antigen HIV Infections Biology CD8-Positive T-Lymphocytes Immunophenotyping Interleukin 21 Antigens CD Reference Values T-Lymphocyte Subsets hemic and lymphatic diseases HIV Seronegativity HIV Seropositivity medicine Immunology and Allergy Cytotoxic T cell Humans Interferon gamma Interleukin 4 Acquired Immunodeficiency Syndrome integumentary system Cell Membrane T-Lymphocytes Helper-Inducer Articles Virology Molecular biology Clone Cells medicine.anatomical_structure HIV-1 Cytokines Cytokine secretion CD8 medicine.drug |
| Zdroj: | The Journal of Experimental Medicine Scopus-Elsevier |
| ISSN: | 0022-1007 |
| Popis: | A large panel of CD8+ T cell clones generated from peripheral blood lymphocytes (PBL) of healthy donors or human immunodeficiency virus (HIV)-infected individuals were assessed for both cytokine secretion profile and CD30 expression and release. The great majority of CD8+ T cell clones generated from healthy individuals showed the ability to produce interferon gamma (IFN-gamma), but not interleukin 4 (IL-4), and none of them either expressed membrane CD30 or released substantial amounts of soluble CD30 (sCD30) in their supernatant. In contrast, high numbers of CD8+ T cell clones generated from HIV-infected individuals, which produced IL-4 (and IL-5) in addition to IFN-gamma or IL-4 (and IL-5) alone, expressed membrane CD30 and released detectable amounts of sCD30 in their supernatants. Indeed, CD30 expression appeared to be positively correlated with the ability of CD8+ T cell clones to produce IL-4 and IL-5 and inversely correlated with their ability to produce IFN-gamma, whereas no correlation between CD30 expression and production of IL-10 was observed. These data suggest that CD30 is a marker for CD8+ T cells that have switched to the production of type 2 helper cytokines. |
| Databáze: | OpenAIRE |
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