BAFF and APRIL expression as an autoimmune signature of membranous nephropathy
| Autor: | Jooyoung Kim, Chun Soo Lim, Hajeong Lee, Sang-Ho Lee, Kwon Wook Joo, Dong Ki Kim, Seung Hee Yang, Hyung Ah Jo, Yon Su Kim, Minkyoung Park, Seung Seok Han, Yun Jung Oh, Jung Pyo Lee |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty 030204 cardiovascular system & hematology medicine.disease_cause Gastroenterology Autoimmunity Pathogenesis 03 medical and health sciences 0302 clinical medicine Membranous nephropathy Internal medicine Biopsy medicine APRIL B-cell activating factor Autoimmune disease Kidney B cells Systemic lupus erythematosus medicine.diagnostic_test business.industry autoimmunity membranous nephropathy medicine.disease 030104 developmental biology medicine.anatomical_structure Oncology BAFF business Research Paper |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| Popis: | // Seung Seok Han 1, 2 , Seung Hee Yang 2 , Hyung Ah Jo 1 , Yun Jung Oh 2 , Minkyoung Park 2 , Joo Young Kim 2 , Hajeong Lee 1, 2 , Jung Pyo Lee 1, 2, 3 , Sang-Ho Lee 4 , Kwon Wook Joo 1, 2 , Chun Soo Lim 1, 3 , Yon Su Kim 1, 2 and Dong Ki Kim 1, 2 1 Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea 2 Kidney Research Institute, Seoul National University, Seoul, Korea 3 Department of Internal Medicine, Seoul National University Boramae Medical Center, Seoul, Korea 4 Department of Internal Medicine, College of medicine, Kyung Hee University, Seoul, Korea Correspondence to: Dong Ki Kim, email: dkkim73@gmail.com Keywords: APRIL; autoimmunity; BAFF; B cells; membranous nephropathy Received: July 03, 2017 Accepted: November 14, 2017 Published: December 14, 2017 ABSTRACT Background: Based on the fact that B-cell activating factor (BAFF) and a proliferation-inducing ligand (APRIL) have a regulatory role in B cell biology, excessive levels of these cytokines can promote autoimmune pathogenesis. However, the expression and implication remain unresolved in cases of membranous nephropathy (MN). Results: The plasma BAFF levels of the primary MN patients were higher than those of healthy controls but lower than those of secondary MN patients, whereas the APRIL levels were similar between the MN patients and healthy controls. The BAFF levels were higher in relapse cases, whereas the APRIL levels were higher in the patients who did not experience remission compared with the counterpart patients. The ectopic expression of BAFF and APRIL was observed in the glomeruli or circulating B cells of MN patients, and this high expression trend was similar to that of lupus patients. Conclusions: Expression profile of BAFF and APRIL in MN is similar to that of other autoimmune disease, which affects the kidney outcomes. Methods: Plasma BAFF and APRIL levels were measured upon kidney biopsy in patients with primary ( n = 89) and secondary MN ( n = 13), and the results were compared with the levels in healthy controls ( n = 111). The kidney outcomes (e.g., remission and relapse) were traced for the median of 3 years. Aberrant expression of the cytokines was evaluated in the kidney and circulating B cells using immunohistochemistry and flow cytometry analyses, respectively. |
| Databáze: | OpenAIRE |
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