Effects of obesity on lung function and airway reactivity in healthy dogs
| Autor: | Jefferson Manens, Cécile Clercx, Nathalie Kirschvink, Frederique Bernaerts, M. Bolognin, Marianne Diez |
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| Rok vydání: | 2012 |
| Předmět: |
Male
medicine.medical_specialty Respiratory rate Bronchoconstriction Respiratory System Agents Bronchial Provocation Tests Pulmonary function testing Doxapram Hydrochloride Dogs Internal medicine Tidal Volume medicine Animals Respiratory function Dog Diseases Obesity Respiratory system Lung Tidal volume Plethysmography Whole Body General Veterinary business.industry Doxapram Endocrinology Injections Intravenous Respiratory Mechanics Animal Science and Zoology business Respiratory minute volume medicine.drug |
| Zdroj: | The Veterinary Journal. 193:217-221 |
| ISSN: | 1090-0233 |
| DOI: | 10.1016/j.tvjl.2011.10.013 |
| Popis: | The present study investigated the effects of bodyweight (BW) gain on respiratory function and airway responsiveness in healthy Beagles using barometric whole body plethysmography (BWBP). Six adult dogs were examined before and after a fattening diet. The high-energy diet induced a mean increase in BW of 41±6%. BWBP basal parameters were recorded prior to airway reactivity testing (using increasing concentrations of histamine nebulisations). An airway responsiveness index (H-Penh300) was calculated as the histamine concentration necessary to reach 300% of basal enhanced pause (Penh, bronchoconstriction index). The same dogs underwent a doxapram hydrochloride (Dxp) stimulation testing 2 weeks later. Basal measurements showed that obese dogs had tidal volume per kg (TV/BW) that was significantly decreased whilst respiratory rate (RR) increased significantly. H-Penh300 decreased significantly in obese Beagles, indicating increased bronchoreactivity. Dxp administration induced a significant increase in TV/BW, minute volume per kg (MV/BW), peak inspiratory and expiratory flows per kg (PIF/BW and PEF/BW) in both normal and obese dogs although the TV/BW increase was significantly less marked in the obese group. In conclusion, obesity induced changes in basal respiratory parameters, increased bronchoreactivity and a blunted response to Dxp-induced respiratory stimulation. This combination of basal respiratory parameters, bronchoreactivity testing and pharmacological stimulation testing using non-invasive BWBP can help characterize pulmonary function and airway responsiveness in obese dogs. |
| Databáze: | OpenAIRE |
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