Neuronal Mechanisms that Drive Organismal Aging Through the Lens of Perception
| Autor: | Tuhin Subhra Chakraborty, Christi M. Gendron, Yang Lyu, Scott D. Pletcher, Zachary M. Harvanek, Jacob C. Johnson, Allyson S. Munneke, Brian Y. Chung, Kristina J. Holme |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Aging Sensory Receptor Cells genetic structures Physiology media_common.quotation_subject Threat perception Sensory system Disease behavioral disciplines and activities Article 03 medical and health sciences 0302 clinical medicine Perception medicine Animals Humans Social isolation Sensory cue media_common Social perception Time perception 030104 developmental biology sense organs Cues medicine.symptom Psychology Neuroscience psychological phenomena and processes 030217 neurology & neurosurgery Signal Transduction |
| Zdroj: | Annual Review of Physiology. 82:227-249 |
| ISSN: | 1545-1585 0066-4278 |
| DOI: | 10.1146/annurev-physiol-021119-034440 |
| Popis: | Sensory neurons provide organisms with data about the world in which they live, for the purpose of successfully exploiting their environment. The consequences of sensory perception are not simply limited to decision-making behaviors; evidence suggests that sensory perception directly influences physiology and aging, a phenomenon that has been observed in animals across taxa. Therefore, understanding the neural mechanisms by which sensory input influences aging may uncover novel therapeutic targets for aging-related physiologies. In this review, we examine different perceptive experiences that have been most clearly linked to aging or age-related disease: food perception, social perception, time perception, and threat perception. For each, the sensory cues, receptors, and/or pathways that influence aging as well as the individual or groups of neurons involved, if known, are discussed. We conclude with general thoughts about the potential impact of this line of research on human health and aging. |
| Databáze: | OpenAIRE |
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