Is radiofrequency thermal ablation a safe and effective procedure in the treatment of pulmonary malignancies?
| Autor: | Hui Xu, Qingshu Cheng, Kunxiang Gao, Xiaofei Li, Yong Han, Xiaoping Wang, Lijun Huang, Jinbo Zhao |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Pulmonary and Respiratory Medicine
Adult Male medicine.medical_specialty Hemoptysis Percutaneous Lung Neoplasms Radiofrequency ablation Pulmonary Surgical Procedures law.invention Young Adult law Cardiac tamponade Carcinoma Non-Small-Cell Lung medicine Humans Aged Neoplasm Staging Aged 80 and over business.industry Patient Selection Respiratory disease Pneumothorax General Medicine Length of Stay Middle Aged medicine.disease Hemothorax Surgery Treatment Outcome Catheter Ablation Disease Progression Female Tamponade Cardiology and Cardiovascular Medicine business |
| Zdroj: | European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery. 39(3) |
| ISSN: | 1873-734X |
| Popis: | Objective: Radiofrequency ablation (RFA) has been recently applied as an alternative option of pulmonary surgery in the treatment of pulmonary malignancies. In this study, we assessed the risk associatedwith percutaneous RFA, and discussed its safety and efficacy. Methods:The clinical data of 329 consecutive patients with primary (n = 237) and metastatic (n = 92) lung tumor treated with RFA from 1999 to 2006 in this hospitalwereconsideredfor thisstudy, andthecharacterandclinicaldataofthesepatientswere analyzed. Complications,localprogression,and overall survival at 1, 2 and 5 years of these patients were evaluated. Results: Following the procedure 63 (19.1%) patients presented with pneumothorax, 14(4.2%) with hemoptysis (onedeath), 10(3.0%) hemothorax, 15(4.5%) pneumonia, andthree (0.9%) pericardial tamponade(one death); the 30-day mortality after the procedure was 0.6%. Needle-track implantation was observed in six (1.8%) patients. Median progressionfree interval was 21.6 months. The overall survival at 1, 2 and 5 years was 68.2%, 35.3%, and 20.1%, respectively. A total of 78 (23.7%) patients developed local progression during the follow-up. Significant difference in the risk of local progression was found in tumors more than 4 cm; however, no significant difference was found in tumors less than 3 cm and 3—4 cm in our group. Conclusion: RAF is a safe and well-tolerated procedure with satisfied efficacy in the treatment of malignant lung nodules. To avoid complications with potential fatal outcome, adequate training and careful patient selection by a multidisciplinary team might be helpful. # 2010 European Association for Cardio-Thoracic Surgery. Published by Elsevier B.V. All rights reserved. |
| Databáze: | OpenAIRE |
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