A randomized controlled study of the effects of different modalities of narrow-band ultraviolet B therapy on the outcome of cultured autologous melanocytes transplantation in treating vitiligo
| Autor: | Xiaodong Wei, Lifang Fu, Weisong Hong, Di-min Zhang, Aie Xu |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Vitiligo Dermatology Ultraviolet B therapy Melanocyte Transplantation Autologous law.invention Young Adult Randomized controlled trial law medicine Humans Young adult skin and connective tissue diseases Child integumentary system business.industry General Medicine Middle Aged medicine.disease Surgery Transplantation Narrow band medicine.anatomical_structure Homogeneous Child Preschool Melanocytes Female Ultraviolet Therapy business |
| Zdroj: | Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]. 40(4) |
| ISSN: | 1524-4725 |
| Popis: | Background Vitiligo is an acquired skin disorder with great social impact. It can be successfully treated using cultured autologous melanocytes transplantation. Objective To evaluate the effect of different modalities of narrow-band ultraviolet B (NB-UVB) therapy on the outcome of cultured autologous melanocyte transplantation in treating vitiligo. Methods Patients undergoing cultured autologous melanocyte transplantation were randomly assigned to four different study groups. Group 1 underwent 20 sessions of NB-UVB treatment before transplantation; Group 2 underwent 30 sessions of NB-UVB treatment after transplantation; Group 3 underwent 20 sessions of NB-UVB treatment before transplantation and 30 sessions after transplantation; Group 4 underwent only transplantation. Results Four hundred thirty-seven patients were enrolled. Group 3 responded best, more than 90% repigmentation was achieved in 81.3% of patients, and 94.8% patients experienced 50% or greater repigmentation. Statistical analysis showed that there was a highly significant difference between the four groups (χ2 = 35.56, p |
| Databáze: | OpenAIRE |
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