Inhibition of histidine decarboxylase and diamine oxidase by 4-bromo-3-hydroxybenzyloxyamine
| Autor: | Kobayashi Yutaka, Jacob Kupelian, David V. Maudsley |
|---|---|
| Rok vydání: | 1970 |
| Předmět: |
Male
medicine.medical_specialty Monoamine Oxidase Inhibitors Time Factors Carboxy-Lyases medicine.medical_treatment Intraperitoneal injection Biology Hydroxylamines Biochemistry Gastrointestinal Hormones Cresols chemistry.chemical_compound In vivo Internal medicine medicine Animals Insulin Histidine Pyridoxal phosphate Pharmacology chemistry.chemical_classification Carbon Isotopes Stomach Diamine oxidase activity Succinates Fasting Histidine decarboxylase Diet Rats Intestines Enzyme Endocrinology chemistry Enzyme Induction Pyridoxal Phosphate Histidine decarboxylase activity Amine Oxidase (Copper-Containing) Diamine oxidase Peptides Histamine |
| Zdroj: | Biochemical Pharmacology. 19:1761-1770 |
| ISSN: | 0006-2952 |
| DOI: | 10.1016/0006-2952(70)90168-1 |
| Popis: | In freely fed rats, an intraperitoneal injection of 0.688 m-mole per kg of 4-bromo-3-hydroxybenzyloxyamine (NSD 1055) produces a transient drop in both the histidine decarboxylase activity of the glandular stomach and the diamine oxidase activity of the intestine. Both enzymes are inhibited by approximately 50 per cent within 30 min, but recovery to normal levels occurs within a few hours. The results obtained in vivo are in sharp contrast to the data in vitro , which show that the inhibitor is much more active against the decarboxylase. The transient effect of NSD 1055 against the two enzymes in vivo may be due primarily to the rapid clearance or metabolism of the drug, while the change in potency ratio from a situation in vitro to one in vivo may reflect the greater rate of turnover of histidine decarboxylase. The drug, however, is very effective in preventing the rise in histidine decarboxylase produced by insulin, pentagastrin or refeeding of starved animals. Presumably under these circumstances there is a greater opportunity for the drug to complex with the cofactor, pyridoxal phosphate. |
| Databáze: | OpenAIRE |
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