Endothelin-1 in idiopathic pulmonary fibrosis
| Autor: | Riccardo Meliconi, Mario Fabbri, Mariagrazia Uguccioni, Annalisa Facchini, Lia Pulsatelli, Giovanni Gasbarrini, Brunella Grigolo, C Cinti, Luca Fasano |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Adult
Male medicine.hormone Pathology medicine.medical_specialty Pulmonary Fibrosis Epithelium Pathology and Forensic Medicine Immunoenzyme Techniques Endothelins Idiopathic pulmonary fibrosis Fibrosis Pulmonary fibrosis Biopsy medicine Humans Endothelium Aged Aged 80 and over Lung medicine.diagnostic_test business.industry Macrophages Respiratory disease General Medicine Middle Aged respiratory system medicine.disease Endothelin 1 humanities respiratory tract diseases medicine.anatomical_structure cardiovascular system Female business Research Article |
| Zdroj: | Journal of Clinical Pathology. 48:330-334 |
| ISSN: | 0021-9746 |
| DOI: | 10.1136/jcp.48.4.330 |
| Popis: | AIMS--To evaluate whether endothelin-1 is involved in the pathology of idiopathic pulmonary fibrosis (IPF). METHODS--Plasma endothelin-1 concentrations were evaluated in 37 patients with IPF and 27 normal controls by radioimmunoassay. In addition, expression of endothelin-1 in lung tissue was evaluated in biopsy specimens obtained from four patients with IPF. Three biopsy specimens of normal lung were used as controls. Endothelin-1 immunoreactivity was detected using immunohistochemistry. RESULTS--Elevated endothelin-1 plasma concentrations were found in patients with IPF compared with controls and a positive correlation was found with duration of disease. No significant difference was observed between treated and untreated patients with IPF. Increased endothelin-1 immunoreactivity was found in lungs of three of four patients with IPF. Endothelin-1 positive consisted mainly of small vessel endothelial cells. Some scattered macrophages were also positive. CONCLUSIONS--Elevated plasma concentrations and expression of endothelin-1 in lung tissue are suggestive of increased production of endothelin-1 in at least a proportion of patients with IPF. Consequently, endothelin-1 activity could play a role in the fibrogenic process of the disease. |
| Databáze: | OpenAIRE |
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