Cancer-Associated Fibroblasts in the Breast Tumor Microenvironment
Autor: | Flavia Piccioni, Norma Alejandra Chasseing, Francisco Raúl Borzone, Vivian Labovsky, María Belén Giorello |
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Rok vydání: | 2021 |
Předmět: |
0301 basic medicine
Cancer Research Stromal cell Carcinogenesis Breast Neoplasms Disease Biology Disease-Free Survival Breast tumor Metastasis 03 medical and health sciences 0302 clinical medicine Breast cancer Cancer-Associated Fibroblasts Tumor Microenvironment medicine Humans Neoplasm Invasiveness Breast Prognosis medicine.disease Phenotype 030104 developmental biology Oncology 030220 oncology & carcinogenesis Clinical diagnosis Cancer research Female Neoplasm Recurrence Local |
Zdroj: | Journal of Mammary Gland Biology and Neoplasia. 26:135-155 |
ISSN: | 1573-7039 1083-3021 |
Popis: | Years of investigation have shed light on a theory in which breast tumor epithelial cells are under the effect of the stromal microenvironment. This review aims to discuss recent findings concerning the phenotypic and functional characteristics of cancer associated fibroblasts (CAFs) and their involvement in tumor evolution, as well as their potential implications for anti-cancer therapy. In this manuscript, we reviewed that CAFs play a fundamental role in initiation, growth, invasion, and metastasis of breast cancer, and also serve as biomarkers in the clinical diagnosis, therapy, and prognosis of this disease. |
Databáze: | OpenAIRE |
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