Evaluation of muscular changes by ultrasound Nakagami imaging in Duchenne muscular dystrophy
| Autor: | Chun-Hao Lu, Frank Leigh Lu, Jeng-Yi Shieh, Wen-Chin Weng, Chia-Wei Lin, Ting-Wei Ee, Kuan-Wen Wu, Chun-Yen Lin, Po-Hsiang Tsui, Wang-Tso Lee |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Adult
medicine.medical_specialty Adolescent Science Duchenne muscular dystrophy Sensitivity and Specificity Article 030218 nuclear medicine & medical imaging 03 medical and health sciences Gastrocnemius muscle Young Adult 0302 clinical medicine Internal medicine medicine Image Processing Computer-Assisted Humans Stage (cooking) Muscular dystrophy Child Muscle Skeletal Ultrasonography Multidisciplinary medicine.diagnostic_test business.industry Ultrasound Magnetic resonance imaging Nakagami distribution medicine.disease Magnetic Resonance Imaging Surgery Muscular Dystrophy Duchenne Case-Control Studies Child Preschool Ambulatory Cardiology Medicine business 030217 neurology & neurosurgery Algorithms |
| Zdroj: | Scientific Reports Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017) |
| ISSN: | 2045-2322 |
| Popis: | Duchenne muscular dystrophy (DMD) is the most common debilitating muscular disorder. Developing a noninvasive measure for monitoring the progression of this disease is critical. The present study tested the effectiveness of using ultrasound Nakagami imaging to evaluate the severity of the dystrophic process. A total of 47 participants (40 with DMD and 7 healthy controls) were recruited. Patients were classified into stage 1 (presymptomatic and ambulatory), stage 2 (early nonambulatory), and stage 3 (late nonambulatory). All participants underwent ultrasound examinations on the rectus femoris, tibialis anterior, and gastrocnemius. The results revealed that the ultrasound Nakagami parameter correlated positively with functional severity in the patients with DMD. The median Nakagami parameter of the gastrocnemius muscle increased from 0.50 to 0.85, corresponding to the largest dynamic range between normal and stage 3. The accuracy, sensitivity, and specificity of diagnosing walking function were 85.52%, 76.31%, and 94.73%, respectively. The Nakagami parameter of the rectus femoris and gastrocnemius muscles correlated negatively with the 6-minute walking distance in the ambulatory patients. Therefore, changes in the Nakagami parameter for the gastrocnemius muscle are suitable for monitoring disease progression in ambulatory patients and for predicting ambulation loss. Ultrasound Nakagami imaging shows potential for evaluating patients with DMD. |
| Databáze: | OpenAIRE |
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